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Showing 1–3 of 3 results
Advanced filters: Author: Laura Streith Clear advanced filters

  • Sialic acid-binding immunoglobulin-type lectins (Siglecs) are a family of immunomodulatory receptors expressed on cells of the hematopoietic lineage. Here the authors demonstrate an approach for the identification of the glycan ligands of Siglecs, which is also applicable to other families of glycan-binding proteins.

    • Emily Rodrigues
    • Jaesoo Jung
    • Matthew S. Macauley
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Abhishek Bhattacherjee et al. investigate the functional differences between human and mouse CD33, an immunomodulatory receptor linked to Alzheimer’s disease. They find that loss of mouse CD33 does not affect cargo uptake in macrophages in contrast to human CD33, which represses phagocytosis when expressed in cells or mice.

    • Abhishek Bhattacherjee
    • Emily Rodrigues
    • Matthew S. Macauley
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-13