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Showing 1–3 of 3 results
Advanced filters: Author: Laure Talarmain Clear advanced filters

  • Systematic assessment of cofactor dependencies of nine transcription factors (TFs) and promoters finds that TFs use unique cofactor combinations to modulate distinct steps in transcription, whereas promoter elements fit into discrete groups where their rate-limiting step for activation influences cofactor compatibility.

    • Charles C. Bell
    • Jesse J. Balic
    • Mark A. Dawson
    Research
    Nature Genetics
    Volume: 56, P: 1181-1192

  • HOXA9 plays an important role in acute myeloid leukaemia (AML), but its relevance for other blood malignancies is unclear. Here, the authors show that HOXA9 has a binary switch function that can clinically stratify AML patients, and model how the interactions with JAK2, TET2 and NOTCH impact myeloproliferative neoplasms.

    • Laure Talarmain
    • Matthew A. Clarke
    • Benjamin A. Hall
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Here the authors develop CRISPR–ChIP to enable the identification of factors required for chromatin regulation. Using this new method, they unveil a functional partitioning of H3K79 methylation into two distinct regulatory units, with important implications in MLL leukemia.

    • Omer Gilan
    • Laure Talarmain
    • Mark A. Dawson
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 1592-1606