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Showing 1–4 of 4 results
Advanced filters: Author: Laureen Willems Clear advanced filters

  • Here, the authors determine the structural basis of how SGO1 protects centromeric cohesin from WAPL-mediated release until the kinetochores and the microtubules have formed functional attachments. In addition, they show that SGO1 and CTCF bind cohesin in a similar manner, suggesting a potential universal mechanism of cohesin control.

    • Alberto García-Nieto
    • Amrita Patel
    • Benjamin D. Rowland
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 853-859

  • The link between 3D genome architecture and gene expression is still far from resolved. Here the authors show that loss of the CDK catalytic subunit of the Mediator complex results in heterochromatic silencing, which can be rescued by stabilization of cohesin on chromatin.

    • Judith H. I. Haarhuis
    • Robin H. van der Weide
    • Elzo de Wit
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • The crystal structure of the SA2–SCC1 subunits of human cohesin in complex with CTCF reveals the molecular basis of the cohesin–CTCF interaction that enables the dynamic regulation of chromatin folding.

    • Yan Li
    • Judith H. I. Haarhuis
    • Daniel Panne
    Research
    Nature
    Volume: 578, P: 472-476