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Showing 1–4 of 4 results
Advanced filters: Author: Laurelle Jackson Clear advanced filters

  • The spike protein of the Omicron variant of SARS-CoV-2 has a higher affinity for ACE2 than Delta, and a marked change in its antigenicity increases Omicron’s evasion of therapeutic and vaccine-elicited neutralizing antibodies.

    • Bo Meng
    • Adam Abdullahi
    • Ravindra K. Gupta
    ResearchOpen Access
    Nature
    Volume: 603, P: 706-714

  • Cross-neutralization assays of early variants and the 501Y.V2 variant of SARS-CoV-2 show that plasma from individuals infected with 501Y.V2 effectively neutralizes all variants, indicating that a vaccine that targets 501Y.V2 may also be effective against other SARS-CoV-2 variants.

    • Sandile Cele
    • Inbal Gazy
    • Alex Sigal
    Research
    Nature
    Volume: 593, P: 142-146

  • The Omicron BA.2.86 subvariant differs from previous variants by over 30 spike mutations. Here, the authors report that BA.2.86 likely evolved in Southern Africa and that its immune escape is not larger than recently circulating SARS-CoV-2 strains. Neither its replication nor its pathogenicity are enhanced in vitro.

    • Khadija Khan
    • Gila Lustig
    • Alex Sigal
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-9

  • Plasma from individuals vaccinated with BNT162b2 exhibits 22-fold less neutralization capacity against Omicron (B.1.1.529) than against an ancestral SARS-CoV-2 strain but residual neutralization is maintained in those with high levels of neutralization of ancestral virus.

    • Sandile Cele
    • Laurelle Jackson
    • Alex Sigal
    ResearchOpen Access
    Nature
    Volume: 602, P: 654-656