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Showing 1–9 of 9 results
Advanced filters: Author: Laurence O. Trussell Clear advanced filters
  • Huang and Trussell show that resting potential of the calyx of Held synapse is controlled by KCNQ5 potassium channels. Unlike most KCNQ channels, which activate only on depolarization, these presynaptic channels activate negative to the resting potential. These channels set the resting conductance and control release probability of the synapse.

    • Hai Huang
    • Laurence O Trussell
    Research
    Nature Neuroscience
    Volume: 14, P: 840-847
  • Cryo-electron microscopy analyses of calcium-permeable AMPA receptors from rat brain show that they are composed primarily of GluA1 and GluA4 subunits, and biochemical studies show that noelin promotes inter-receptor interactions without modulating receptor function.

    • Chengli Fang
    • Cathy J. Spangler
    • Eric Gouaux
    ResearchOpen Access
    Nature
    Volume: 645, P: 526-534
  • Electrical coupling in the brain usually occurs between inhibitory neurons that are anatomically and functionally similar. Here the authors show that the excitability of inhibitory interneurons in the dorsal cochlear nucleus is controlled by electrical synapses with excitatory projection cells.

    • Pierre F Apostolides
    • Laurence O Trussell
    Research
    Nature Neuroscience
    Volume: 16, P: 1764-1772
  • Fast-acting neurotransmitters are usually cleared quickly from synaptic regions, making the time course of synaptic responses independent of active sites. The authors describe an exception to this rule at glycinergic synapses on granule cells of the dorsal cochlear nucleus.

    • Veeramuthu Balakrishnan
    • Sidney P Kuo
    • Laurence O Trussell
    Research
    Nature Neuroscience
    Volume: 12, P: 286-294
  • The authors report that rat brain glutamatergic synaptic vesicles express monovalent cation/H+ exchangers that convert the Δψ of the proton electrochemical gradient into Δψ. They find that this K+/H+ exchange stimulates the accumulation of glutamate into vesicles, regulating glutamate release and thus synaptic transmission.

    • Germaine Y Goh
    • Hai Huang
    • Robert H Edwards
    Research
    Nature Neuroscience
    Volume: 14, P: 1285-1292
  • In cochlear hair cells, each transmitter release site communicates information about sound frequency and intensity. Now the first direct electrophysiological recordings from the structures postsynaptic to these sites show that they function very differently from brain synapses.

    • Laurence O. Trussell
    News & Views
    Nature Neuroscience
    Volume: 5, P: 85-86