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Showing 1–6 of 6 results
Advanced filters: Author: Laurent Mailly Clear advanced filters

  • The circadian factors BMAL1/CLOCK and REV-ERB are master regulators of the human liver transcriptome but their role in hepatitis B virus infection is largely unknown. Here, Zhuang et al. show that REV-ERB regulates hepatitis B virus entry and BMAL1 directly binds HBV DNA and activates viral genome transcription.

    • Xiaodong Zhuang
    • Donall Forde
    • Jane A. McKeating
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Single-cell RNA sequencing of cells from healthy human liver, hepatocellular carcinoma and chimaeric mouse liver identifies subtypes of liver cells, epithelial progenitors and differences between healthy and diseased cells.

    • Nadim Aizarani
    • Antonio Saviano
    • Dominic Grün
    Research
    Nature
    Volume: 572, P: 199-204

  • Striatal GABAergic interneurons regulate the influence of cortical inputs on striatal projection neurons through feedforward inhibition. Here, the authors report that this inhibition is mediated mainly by PV interneurons in the dorsolateral striatum and SOM interneurons in the dorsomedial striatum.

    • Elodie Fino
    • Marie Vandecasteele
    • Laurent Venance
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • The investigation of virus-induced liver disease and hepatocellular carcinoma needs small animal models modeling hepatitis C virus (HCV) infection and liver disease biology. A recent study published in Cell Research reports a novel mouse model which is permissive for chronic HCV infection and shows chronic liver injury including inflammation, steatosis and fibrosis.

    • Rajiv G Tawar
    • Laurent Mailly
    • Thomas F Baumert
    Research Highlights
    Cell Research
    Volume: 24, P: 1153-1154