In Drosophila, protein kinase A (PKA) phosphorylates the transcription factor Cubitus interruptus (Ci) in the absence of Hedgehog signalling and the transducer Smoothened in its presence. Here, the authors investigate the mechanism underlying this switch and propose that Smoothened outcompetes Ci for association with PKA on Hedgehog signalling activation.
- Nadia Ranieri
- Pascal P. Thérond
- Laurent Ruel
