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Advanced filters: Author: Lautaro Diacovich Clear advanced filters

Bacterial manipulation of innate immunity to promote infection

The mammalian innate immune system recognizes invading pathogens and targets them with an arsenal of cellular defences. In this Review, Diacovich and Gorvel describe how pathogenic intracellular bacteria use a range of strategies to subvert innate immune responses.

Lautaro Diacovich
Jean-Pierre Gorvel
Reviews01 Feb 2010
Nature Reviews Microbiology

Volume: 8, P: 117-128
Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine

FasR is a TetR-like transcriptional activator that plays a central role in sensing mycobacterial long-chain fatty acids and regulating lipid biosynthesis in Mycobacterium tuberculosis. Here authors present crystal structures of M. tuberculosis FasR in complex with acyl effector ligands and with DNA, uncovering its molecular sensory and switching mechanisms.

Julia Lara
Lautaro Diacovich
Alejandro Buschiazzo
ResearchOpen Access24 Jul 2020
Nature Communications

Volume: 11, P: 1-13
Blue light directly modulates the quorum network in the human pathogen Acinetobacter baumannii

Marisel Romina Tuttobene
Gabriela Leticia Müller
María Alejandra Mussi
ResearchOpen Access28 Jun 2021
Scientific Reports

Volume: 11, P: 1-20

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