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Showing 1–50 of 76 results

Advanced filters: Author: Lawrence Steinman Clear advanced filters

Suppressive vaccination with DNA encoding a variable region gene of the T–cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity

Ari Waisman
Pedro J. Ruiz
Lawrence Steinman
Research01 Aug 1996
Nature Medicine

Volume: 2, P: 899-905
Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen

Stefan Brocke
Amitabh Gaur
Lawrence Steinman
Research01 Oct 1993
Nature

Volume: 365, P: 642-644
Dehydration Condensation in Aqueous Solution

GARY STEINMAN
DEAN H. KENYON
MELVIN CALVIN
Research01 May 1965
Nature

Volume: 206, P: 707-708
Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

Stefan Brocke
Koenraad Gijbels
Lawrence Steinman
Research25 Jan 1996
Nature

Volume: 379, P: 343-346
Selection for T-cell receptor Vβ–Dβ–Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis

Jorge R. Oksenberg
Michael A. Panzara
Lawrence Steinman
Research01 Mar 1993
Nature

Volume: 362, P: 68-70
T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination

Scott Zamvil
Patricia Nelson
Lawrence Steinman
Research26 Sept 1985
Nature

Volume: 317, P: 355-358
Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

Ted A. Yednock
Catherine Cannon
Nathan Karin
Research05 Mar 1992
Nature

Volume: 356, P: 63-66
Presenting an odd autoantigen

Lawrence Steinman
News & Views29 Jun 1995
Nature

Volume: 375, P: 739-740
Normal dystrophin transcripts detected in Duchenne muscular dystrophy patients after myoblast transplantation

Emanuela Gussoni
Grace K. Pavlath
Helen M. Blau
Research02 Apr 1992
Nature

Volume: 356, P: 435-438
Erratum: Limited heterogeneity of rearranged T-cell receptor V α transcripts in brains of multiple sclerosis patients

Jorge R. Oksenberg
Simon Stuart
Claude C. A. Bernard
Amendments and Corrections05 Sept 1991
Nature

Volume: 353, P: 94
Idiotypic immunization induces immunity to mutated p53 and tumor rejection

Pedro J. Ruiz
Roland Wolkowicz
Irun R. Cohen
Research01 Jun 1998
Nature Medicine

Volume: 4, P: 710-712
Regulation of autosensitisation to encephalitogenic myelin basic protein by macrophage-associated and soluble antigen

LAWRENCE STEINMAN
IRUN R. COHEN
RUTH ARNON
Research01 Jan 1977
Nature

Volume: 265, P: 173-175
The right stuff: Breaking through the xenotransplant barrier

Permanent acceptance of a skin xenograft was achieved by induction of tolerance in the recipient (pages 1211–1216).

Lawrence Steinman
News & Views01 Nov 1996
Nature Medicine

Volume: 2, P: 1185-1186
Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine

Marcela V. Karpuj
Mark W. Becher
Lawrence Steinman
Research01 Feb 2002
Nature Medicine

Volume: 8, P: 143-149
Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients

Jorge R. Oksenberg
Simon Stuart
Claude C. A. Bernard
Research24 May 1990
Nature

Volume: 345, P: 344-346
T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis

Scott S. Zamvil
Dennis J. Mitchell
Jonathan B. Rothbard
Research20 Nov 1986
Nature

Volume: 324, P: 258-260
Blocking adhesion molecules as therapy for multiple sclerosis: natalizumab

Lawrence Steinman
Reviews01 Jun 2005
Nature Reviews Drug Discovery

Volume: 4, P: 510-518
A molecular trio in relapse and remission in multiple sclerosis

The relapsing-remitting form of multiple sclerosis affects around two thirds of patients with this disease. This Review discusses the roles of three key molecules — α4β1 integrin, its binding partner osteopontin and the chaperone protein αB crystallin — in the biology of relapse and remission.

Lawrence Steinman
Reviews01 Jun 2009
Nature Reviews Immunology

Volume: 9, P: 440-447
Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin

Aimin Tang
Masayuki Amagai
Mark C. Uddy
Research07 Jan 1993
Nature

Volume: 361, P: 82-85
More mayhem from molecular mimics

Antibodies against human herpesvirus-6 have been found in patients with multiple sclerosis. Could this be another sighting in the hunt for the viral trigger of the disease (pages 1394–1397)?

Lawrence Steinman
Michael B.A. Oldstone
News & Views01 Dec 1997
Nature Medicine

Volume: 3, P: 1321-1322
Erratum: Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

Stefan Brocke
Koenraad Gijbels
Lawrence Steinman
Amendments and Corrections09 Apr 1998
Nature

Volume: 392, P: 630
Cell cycle re-entry following chemically-induced cell cycle synchronization leads to elevated p53 and p21 protein levels

Chuan Ji
Lawrence J Marnett
Jennifer A Pietenpol
Research27 Nov 1997
Oncogene

Volume: 15, P: 2749-2753
Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis

William H Robinson
Paulo Fontoura
Lawrence Steinman
Research10 Aug 2003
Nature Biotechnology

Volume: 21, P: 1033-1039
Drug Insight: using statins to treat neuroinflammatory disease

Statins are best known for their cholesterol-lowering effects, but they also have immunomodulatory properties that might be exploited to treat neuroinflammatory disorders, such as multiple sclerosis. This review describes the molecular and cellular mechanisms that are thought to underlie the immunomodulatory effects, and discusses the results of initial clinical trials of statins in patients with multiple sclerosis.

Martin S Weber
Thomas Prod'homme
Scott S Zamvil
Reviews01 Dec 2005
Nature Clinical Practice Neurology

Volume: 1, P: 106-112
Viral damage and the breakdown of self-tolerance

Theiler's virus induces breakdown of tolerance to myelin and initiates a multiple sclerosis-like autoimmune disease in mice (pages 1133–1136).

Lawrence Steinman
Paul Conlon
News & Views01 Oct 1997
Nature Medicine

Volume: 3, P: 1085-1087
Erratum: A brief history of T_H17, the first major revision in the T_H1/T_H2 hypothesis of T cell–mediated tissue damage

Lawrence Steinman
Amendments and Corrections01 Mar 2007
Nature Medicine

Volume: 13, P: 385
Lipid microarrays identify key mediators of autoimmune brain inflammation

Jennifer L Kanter
Sirisha Narayana
William H Robinson
Research11 Dec 2005
Nature Medicine

Volume: 12, P: 138-143
A Tip leads cytotoxic T cells to the crime scene in neuroinflammation

By increasing the range of epitopes presented to lymphocytes, determinant spreading allows a more diverse response to ensue. Now the cellular culprits responsible for determinant spreading in the central nervous system have been identified: they are specialized dendritic cells that recruit CD8⁺ T cells to an autoimmune 'crime'.

Lawrence Steinman
News & Views15 Feb 2013
Nature Immunology

Volume: 14, P: 196-197
Gaining entry to an uninflamed brain

Little is known about how pathogenic T cells gain access to the uninflamed brain in multiple sclerosis and experimental autoimmune encephalomyelitis. A new study reports that interleukin 17–producing T helper cells enter the uninflamed central nervous system through the choroid plexus by a CCR6-CCL20–dependent mechanism.

Robert C Axtell
Lawrence Steinman
News & Views01 May 2009
Nature Immunology

Volume: 10, P: 453-455
Erratum: Common variants in P2RY11 are associated with narcolepsy

Birgitte R Kornum
Minae Kawashima
Emmanuel Mignot
Amendments and Corrections28 Sept 2011
Nature Genetics

Volume: 43, P: 1040
Human peptidome display

A peptide library representing the entire human proteome is applied to the discovery of autoantigens.

William H Robinson
Lawrence Steinman
News & Views07 Jun 2011
Nature Biotechnology

Volume: 29, P: 500-502
Weighing In On Autoimmune Disease: 'Hub-and-spoke' T cell traffic in autoimmunity

Lawrence Steinman
Comments & Opinion06 Feb 2013
Nature Medicine

Volume: 19, P: 139-141
Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

Christopher Lock
Guy Hermans
Lawrence Steinman
Research01 May 2002
Nature Medicine

Volume: 8, P: 500-508
Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial

Ludwig Kappos
Giancarlo Comi
Xin-Jun Liu
Research01 Oct 2000
Nature Medicine

Volume: 6, P: 1176-1182
Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

May H. Han
Sun-Il Hwang
Lawrence Steinman
Research17 Feb 2008
Nature

Volume: 451, P: 1076-1081
T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis

Interferon-β (IFN-β) is a mainstay therapy for multiple sclerosis. However, only two thirds of patients respond to therapy, and clinical symptoms worsen in some patients. Chandar Raman and his colleagues show that IFN-β alleviates disease induced by T helper type 1 cells and exacerbates disease induced by T helper type 17 cells in mice. They also show that these effects of IFN-β rely on IFN-γ signaling (pages 376–377).

Robert C Axtell
Brigit A de Jong
Chander Raman
Research28 Mar 2010
Nature Medicine

Volume: 16, P: 406-412
An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide

Rosetta Pedotti
Dennis Mitchell
Lawrence Steinman
Research01 Mar 2001
Nature Immunology

Volume: 2, P: 216-222
Hunger guides immunity to friend versus foe

Both caloric restriction and obesity affect autoimmune diseases. The activation of brainstem neurons in the ventrolateral medulla (VLM) with fasting suppresses experimental autoimmune diseases. Stimulation of VLM neurons alters T cell traffic by redistributing immune cells to bone marrow and reduces inflammatory cytokine production, thus providing therapy of experimental autoimmunity.

Noga Or-Geva
Lawrence Steinman
News & Views15 Feb 2024
Nature Neuroscience

Volume: 27, P: 393-394
Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system

Modulating the entry of inflammatory T cells into the brain could be one way to treat the autoimmune disease multiple sclerosis. Now, Frauke Zipp and colleagues demonstrate that activation of kinin receptor B1 can block autoimmune T cell migration into the brain and can therefore inhibit experimental autoimmune encephalomyelitis in mice.

Ulf Schulze-Topphoff
Alexandre Prat
Frauke Zipp
Research28 Jun 2009
Nature Medicine

Volume: 15, P: 788-793
Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis

Hematopoietic cell transplantation (HCT) may be a promising therapy for treatment-refractory multiple sclerosis (MS). Mader et al. Describe beneficial effects of autologous HCT in a mouse model of MS and identify a myeloid transcriptional signature associated with neuroprotection.

Marius Marc-Daniel Mader
Alan Napole
Marius Wernig
Research21 Mar 2024
Nature Neuroscience

Volume: 27, P: 901-912
Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue

Regulatory T cell (T_reg) maintenance and function require IL-2, yet this cytokine is only present in low levels in vivo. In this study, the authors demonstrate that that T_reg use heparanase to access IL-2 bound to heparan sulfate proteoglycans in the extracellular matrix of inflamed brain tissue in mice.

Hunter A. Martinez
Ievgen Koliesnik
Hedwich F. Kuipers
ResearchOpen Access20 Feb 2024
Nature Communications

Volume: 15, P: 1-15
Transcriptional analysis of targets in multiple sclerosis

Lawrence Steinman
Scott Zamvil
Reviews01 Jun 2003
Nature Reviews Immunology

Volume: 3, P: 483-492
Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells

Eun Mi Hur
Sawsan Youssef
Lawrence Steinman
Research03 Dec 2006
Nature Immunology

Volume: 8, P: 74-83
Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models

Myeloid cells are critical in the pathology of inflammatory and degenerative brain diseases. The authors use single-cell mass cytometry (CyTOF) to reveal distinct characteristics in these cells in models of neural inflammation and degeneration.

Bahareh Ajami
Nikolay Samusik
Lawrence Steinman
Research05 Mar 2018
Nature Neuroscience

Volume: 21, P: 541-551
Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM

The identification of high-affinity molecular mimicry between the Epstein–Barr virus (EBV) transcription factor EBNA1 and the CNS protein GlialCAM provides a mechanistic link between multiple sclerosis and EBV.

Tobias V. Lanz
R. Camille Brewer
William H. Robinson
Research24 Jan 2022
Nature

Volume: 603, P: 321-327
Multiple approaches to multiple sclerosis

Lawrence Steinman
News & Views01 Jan 2000
Nature Medicine

Volume: 6, P: 15-16
Statin therapy and autoimmune disease: from protein prenylation to immunomodulation

Statins are best known as cholesterol-lowering drugs but increasing evidence indicates that they might be an effective treatment for autoimmune disease. Their ability to inhibit post-translational protein prenylation could be key to their immunomodulatory effects.

John Greenwood
Lawrence Steinman
Scott S. Zamvil
Reviews01 May 2006
Nature Reviews Immunology

Volume: 6, P: 358-370
PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

Macrophages coordinate the disposal of apoptotic cells. Ajay Chawla and his colleagues show that PPAR-δ, a sensor of fatty acids, is involved in this process. Ingestion of apoptotic cells by macrophages prompts the upregulation of PPAR-δ, which then responds by enhancing the expression of opsonins. Lack of PPAR-δ reduces apoptotic cell clearance and predisposes to autoimmunity (pages 1246–1248).

Lata Mukundan
Justin I Odegaard
Ajay Chawla
Research18 Oct 2009
Nature Medicine

Volume: 15, P: 1266-1272
Defective sphingosine 1-phosphate receptor 1 (S1P₁) phosphorylation exacerbates T_H17-mediated autoimmune neuroinflammation

S1P₁ is a sphingosine phosphate receptor expressed on lymphocytes. Han and colleagues show that phosphorylated S1P₁ accumulates in brain lesions of patients with multiple sclerosis. Similarly, mice bearing mutant S1P₁ develop more severe experimental autoimmune encephalomyelitis.

Christopher S Garris
Linfeng Wu
May H Han
Research29 Sept 2013
Nature Immunology

Volume: 14, P: 1166-1172
Type II monocytes modulate T cell–mediated central nervous system autoimmune disease

Martin S Weber
Thomas Prod'homme
Scott S Zamvil
Research05 Aug 2007
Nature Medicine

Volume: 13, P: 935-943

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