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Showing 1–5 of 5 results
Advanced filters: Author: Lay Kodama Clear advanced filters

  • Kodama et al. use electronic health record data of patients with and without a delirium diagnosis to identify the comorbidities and laboratory values associated with inpatient delirium diagnoses. Longitudinal analysis also show that an inpatient delirium diagnosis is associated with an increased risk of mortality independent of comorbidity burden.

    • Lay Kodama
    • Sarah R. Woldemariam
    • Marina Sirota
    ResearchOpen Access
    Communications Medicine
    Volume: 5, P: 1-12

  • Kodama et al. show that microglia from male and female adult mice have distinct microRNA profiles and that loss of microglial microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology.

    • Lay Kodama
    • Elmer Guzman
    • Li Gan
    Research
    Nature Neuroscience
    Volume: 23, P: 167-171

  • Dräger et al. establish a rapid, scalable platform for iPSC-derived microglia. CRISPRi/a screens uncover roles of disease-associated genes in phagocytosis, and regulators of disease-relevant microglial states that can be targeted pharmacologically.

    • Nina M. Dräger
    • Sydney M. Sattler
    • Martin Kampmann
    ResearchOpen Access
    Nature Neuroscience
    Volume: 25, P: 1149-1162

  • Wang et al show that microglial NF-κB activation is essential for tau spreading and tau-mediated spatial learning and memory deficits in tauopathy mice. Inactivation of NF-κB reversed tau associated microglial states and rescued autophagy deficits.

    • Chao Wang
    • Li Fan
    • Li Gan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • Human, mouse and iPSC-derived microglia demonstrate that interaction between GRN and phagocytic receptors can rescue (MERTK) or worsen (AXL) FTD-disease features. CSF MERTK maybe a biomarker of symptomatic disease conversion in genetic FTD.

    • Claire Dudley Clelland
    • Li Fan
    • Li Gan
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-14