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Platelets promote tumour metastasis via interaction between TLR4 and tumour cell-released high-mobility group box1 protein

Factors affecting the fate of disseminating tumour cells in the circulation play a critical role in metastasis. Here the authors show that TLR4 on platelets promotes their adhesion to tumour cells and enhances metastasis.

Le-Xing Yu
Lei Yan
Hong-Yang Wang
Research28 Oct 2014
Nature Communications

Volume: 5, P: 1-13
Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

Subpopulations of cytokine-producing and myofibroblastic hepatic stellate cells, identified by single-cell RNA sequencing, protect against or promote the development of hepatocellular carcinoma via high expression of hepatocyte growth factor or type I collagen, respectively..

Aveline Filliol
Yoshinobu Saito
Robert F. Schwabe
Research05 Oct 2022
Nature

Volume: 610, P: 356-365
The gut microbiome and liver cancer: mechanisms and clinical translation

Increasing evidence suggests that the gut microbiota are important modulators of chronic liver disease progression and the development of hepatocellular carcinoma. In this Review, Yu and Schwabe discuss the mechanisms by which the gut microbiota promote hepatocarcinogenesis, and explore therapeutic interventions with clinical potential.

Le-Xing Yu
Robert F. Schwabe
Reviews05 Jul 2017
Nature Reviews Gastroenterology & Hepatology

Volume: 14, P: 527-539
Identification of important genes and drug repurposing based on clinical-centered analysis across human cancers

Ying Li
Ya-ping Dong
Hong-yang Wang
Research18 Jun 2020
Acta Pharmacologica Sinica

Volume: 42, P: 282-289
Role of nonresolving inflammation in hepatocellular carcinoma development and progression

Le-Xing Yu
Yan Ling
Hong-Yang Wang
ReviewsOpen Access23 Feb 2018
npj Precision Oncology

Volume: 2, P: 1-10

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Platelets promote tumour metastasis via interaction between TLR4 and tumour cell-released high-mobility group box1 protein

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

The gut microbiome and liver cancer: mechanisms and clinical translation

Identification of important genes and drug repurposing based on clinical-centered analysis across human cancers

Role of nonresolving inflammation in hepatocellular carcinoma development and progression

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