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Showing 1–2 of 2 results
Advanced filters: Author: Lea Lekieffre Clear advanced filters

  • Adoptive T-cell immunotherapy offers promise to patients who are resistant to standard anti-viral strategies. Here the authors describe clinical observations in patients with viral complications treated with adoptive immunotherapy over the last 15 years.

    • Michelle A. Neller
    • George R. Ambalathingal
    • Rajiv Khanna
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • Biophysical analysis reveals that conserved G-rich sequences within the mRNAs of gammaherpesvirus genome maintenance proteins (GMPs) form G-quadruplexes (G4). Stabilization of mRNA G4 motifs represses GMP translation, whereas destabilization enhances translation, suggesting that these RNA elements are cis-acting translational regulators of proteins involved in viral latency.

    • Pierre Murat
    • Jie Zhong
    • Judy Tellam
    Research
    Nature Chemical Biology
    Volume: 10, P: 358-364