Nature Search

Circulating tumor DNA-guided adjuvant therapy in locally advanced colon cancer: the randomized phase 2/3 DYNAMIC-III trial

As presented at the ESMO Congress 2025: Results of the phase 2/3 AGITG DYNAMIC-III trial show that de-escalated chemotherapy based on ctDNA-negative status in patients with stage III colon cancer did not meet non-inferiority for 3-year recurrence-free survival when compared to standard of care, although it enables better informed treatment decisions.

Jeanne Tie
Yuxuan Wang
Petr Kavan
Research20 Oct 2025
Nature Medicine

Volume: 31, P: 4291-4300
Mutant KRAS vaccine with dual checkpoint blockade in resected pancreatic cancer: a phase I trial

KRAS mutations are keenly associated with pancreatic ductal adenocarcinoma and represent a potential therapeutic target. Here the authors present the findings from a phase I clinical trial testing pooled KRAS mutant peptides in combination with immune checkpoint blockade in patients with resected pancreatic ductal adenocarcinoma.

Amanda L. Huff
S. Daniel Haldar
Neeha Zaidi
ResearchOpen Access10 Feb 2026
Nature Communications

Volume: 17, P: 1-18
NXPE1 alters the sialoglycome by acetylating sialic acids in the human colon

Sialic acids are key cell-surface glycans that regulate immune signaling and cellular recognition. Here, the authors show that NXPE1 encodes a sialic acid O-acetyltransferase, revealing its role in modulating glycan-mediated signaling.

Bum Seok Lee
Ashley Cook
Nicolas Wyhs
ResearchOpen Access27 May 2025
Nature Communications

Volume: 16, P: 1-14
Circulating tumor DNA analysis guiding adjuvant therapy in stage II colon cancer: 5-year outcomes of the randomized DYNAMIC trial

An updated analysis of the DYNAMIC biomarker-driven trial, including mature survival data at 5 years, supports a ctDNA-guided approach to adjuvant chemotherapy for stage II colon cancer.

Jeanne Tie
Yuxuan Wang
Peter Gibbs
Research07 Mar 2025
Nature Medicine

Volume: 31, P: 1509-1518
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Niamh Mullins
Andreas J. Forstner
Ole A. Andreassen
Research17 May 2021
Nature Genetics

Volume: 53, P: 817-829
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

This study uses gene expression predictors for the dorsolateral prefrontal cortex and other brain regions to perform a transcriptomic imputation analysis of schizophrenia, identifying 413 genic associations across 13 brain regions and 36 significantly enriched pathways.

Laura M. Huckins
Amanda Dobbyn
Eli A. Stahl
Research25 Mar 2019
Nature Genetics

Volume: 51, P: 659-674
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease

Genome-wide meta-analysis of SARS-CoV-2 susceptibility and severity phenotypes in up to 756,646 samples identifies a rare protective variant proximal to ACE2. A 6-SNP genetic risk score provides additional predictive power when added to known risk factors.

Julie E. Horowitz
Jack A. Kosmicki
Manuel A. R. Ferreira
ResearchOpen Access03 Mar 2022
Nature Genetics

Volume: 54, P: 382-392
Genome-wide association study identifies 30 loci associated with bipolar disorder

Genome-wide analysis identifies 30 loci associated with bipolar disorder, allowing for comparisons of shared genes and pathways with other psychiatric disorders, including schizophrenia and depression.

Eli A. Stahl
Gerome Breen
Pamela Sklar
Research01 May 2019
Nature Genetics

Volume: 51, P: 793-803
Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone

Durable agonism of NPR1 achieved with a novel investigational monoclonal antibody could mirror the positive hemodynamic changes in blood pressure and heart failure identified in humans with lifelong exposure to NPR1 coding variants.

Michael E. Dunn
Aaron Kithcart
Lori Morton
ResearchOpen Access11 Sept 2024
Nature

Volume: 633, P: 654-661
Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients

Inflammatory bowel disease (IBD) is highly prevalent among the Ashkenazi Jewish population. Here, the authors identify novel IBD-associated variants and genes, validated by transcriptomic and phenome-wide associations.

Yiming Wu
Kyle Gettler
Yuval Itan
ResearchOpen Access20 Apr 2023
Nature Communications

Volume: 14, P: 1-12
Rare coding variants in CHRNB2 reduce the likelihood of smoking

An exome-wide association study of six smoking phenotypes in up to 749,459 individuals identifies associations of rare coding variants in CHRNB2 that may reduce the likelihood of smoking.

Veera M. Rajagopal
Kyoko Watanabe
Giovanni Coppola
ResearchOpen Access12 Jun 2023
Nature Genetics

Volume: 55, P: 1138-1148
High heritability of ascending aortic diameter and trans-ancestry prediction of thoracic aortic disease

Trans-ancestry genome-wide analyses identify multiple loci associated with ascending aortic diameter. A polygenic score constructed from these loci predicted prevalent risk of thoracic aortic aneurysm in independent populations.

Catherine Tcheandjieu
Ke Xiao
James R. Priest
Research30 May 2022
Nature Genetics

Volume: 54, P: 772-782
Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

Laura M. Huckins
Amanda Dobbyn
Eli A. Stahl
Amendments and Corrections13 May 2019
Nature Genetics

Volume: 51, P: 1068
Transcriptional profiling in microglia across physiological and pathological states identifies a transcriptional module associated with neurodegeneration

Analysis of human microglia across health and disease identifies key gene sets in neurodegeneration, offering insights into their role in CNS disorders.

Aysegul Guvenek
Neelroop Parikshak
Giovanni Coppola
ResearchOpen Access18 Sept 2024
Communications Biology

Volume: 7, P: 1-11
Population-scale analysis of common and rare genetic variation associated with hearing loss in adults

A GWAS and exome-wide association study meta-analysis identifies 53 loci affecting hearing loss risk from over half a million individuals across five cohorts. Rare variants in Mendelian hearing loss genes contribute to hearing loss risk in adults.

Kavita Praveen
Lee Dobbyn
Giovanni Coppola
ResearchOpen Access03 Jun 2022
Communications Biology

Volume: 5, P: 1-12
Risk of lymphoid malignancy associated with cancer predisposition genes

Nicholas J. Boddicker
Raphael Mwangi
James R. Cerhan
ResearchOpen Access19 Apr 2025
Blood Cancer Journal

Volume: 15, P: 1-9
ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma

Rare variant association data from human genetics combined with in vitro and in vivo functional validation highlight ANGPTL7 as a promising therapeutic target for intraocular pressure reduction, and protection from glaucoma.

Kavita Praveen
Gaurang C. Patel
Giovanni Coppola
ResearchOpen Access03 Oct 2022
Communications Biology

Volume: 5, P: 1-15
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Till F. M. Andlauer
Jose Guzman-Parra
Marcella Rietschel
ResearchOpen Access11 Nov 2019
Molecular Psychiatry

Volume: 26, P: 1286-1298
Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

Solveig K. Sieberts
Thanneer M. Perumal
Lara M. Mangravite
ResearchOpen Access12 Oct 2020
Scientific Data

Volume: 7, P: 1-11

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Circulating tumor DNA-guided adjuvant therapy in locally advanced colon cancer: the randomized phase 2/3 DYNAMIC-III trial

Mutant KRAS vaccine with dual checkpoint blockade in resected pancreatic cancer: a phase I trial

NXPE1 alters the sialoglycome by acetylating sialic acids in the human colon

Circulating tumor DNA analysis guiding adjuvant therapy in stage II colon cancer: 5-year outcomes of the randomized DYNAMIC trial

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease

Genome-wide association study identifies 30 loci associated with bipolar disorder

Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone

Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients

Rare coding variants in CHRNB2 reduce the likelihood of smoking

High heritability of ascending aortic diameter and trans-ancestry prediction of thoracic aortic disease

Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

Transcriptional profiling in microglia across physiological and pathological states identifies a transcriptional module associated with neurodegeneration

Population-scale analysis of common and rare genetic variation associated with hearing loss in adults

Risk of lymphoid malignancy associated with cancer predisposition genes

ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

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