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Phenotypic convergence and collateral susceptibility development in Pseudomonas aeruginosa under antibiotic exposure in ICU patients

Thomas E. van der Schalk
Matilda Berkell
Christopher Polk
ResearchOpen Access08 May 2026
npj Antimicrobials and Resistance

P: 1-16
Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients

Here, Caballero et al. provide an in depth characterisation of patients colonized with single or mixed strains of Pseudomonas aeruginosa to demonstrate the impact of within-host diversity on the development of antibiotic resistance.

Julio Diaz Caballero
Rachel M. Wheatley
R. Craig MacLean
ResearchOpen Access12 Jul 2023
Nature Communications

Volume: 14, P: 1-12
Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient

In this paper the authors show that the pathogenic bacterium Pseudomonas aeruginosa migrates between the gut and lungs of an ICU patient, and that differential evolutionary responses to antibiotic treatment occur in these organs.

Rachel M. Wheatley
Julio Diaz Caballero
R. Craig MacLean
ResearchOpen Access22 Nov 2022
Nature Communications

Volume: 13, P: 1-11
Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection

Here, following a patient with severe acute Pseudomonas aeruginosa infection, the authors combine comprehensive isolate characterization from lung and gut samples (>100 isolates) and patient clinical data to provide insights into bacterial responses to antibiotic therapy.

Rachel Wheatley
Julio Diaz Caballero
Craig MacLean
ResearchOpen Access28 Apr 2021
Nature Communications

Volume: 12, P: 1-12

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Phenotypic convergence and collateral susceptibility development in Pseudomonas aeruginosa under antibiotic exposure in ICU patients

Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients

Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient

Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection

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Phenotypic convergence and collateral susceptibility development in Pseudomonas aeruginosa under antibiotic exposure in ICU patients

Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients

Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient

Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection

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