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Showing 1–7 of 7 results
Advanced filters: Author: Leendert W. Hamoen Clear advanced filters

  • The bactericidal activity of several antibiotics partially relies on production of reactive oxygen species (ROS), which requires the Fenton reaction. Here, the authors show that membrane depolarization also leads to ROS production, but this occurs via other mechanisms that do not require the Fenton reaction.

    • Declan A. Gray
    • Biwen Wang
    • Leendert W. Hamoen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Hi-C and live-imaging data show that nucleoprotein complexes containing the transcription factor Rok interact over long distances in the bacterium Bacillus subtilis. Rok-dependent interactions contribute to anchored chromosomal loop formation.

    • Gaurav Dugar
    • Andreas Hofmann
    • Leendert W. Hamoen
    Research
    Nature Genetics
    Volume: 54, P: 194-201

  • Bacteria can become dormant or form spores when starved for nutrients. Here, Gray et al. describe an alternative strategy, or ‘oligotrophic growth state’, showing that non-sporulating Bacillus subtilis cells can survive deep starvation conditions by adopting an almost coccoid shape and extremely low growth rates.

    • Declan A. Gray
    • Gaurav Dugar
    • Leendert W. Hamoen
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • The formation of lipid domains in eukaryotic cells is controlled by the cortical actin cytoskeleton. Here, the authors show that the bacterial actin homologue MreB has a comparable activity, influencing the formation of regions of increased fluidity that determine the distribution of membrane proteins.

    • Henrik Strahl
    • Frank Bürmann
    • Leendert W. Hamoen
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-11

  • Wenzel et al. developed a flat embedding method for TEM, which increases the fraction of appropriately orientated cells per image, making it easier to quantify cell morphology. They find that tetracycline-treated B. subtilis shows membrane lesions and that tetracycline action is via direct perturbation of bacterial cell membrane in addition to its known ribosome inhibition activity.

    • Michaela Wenzel
    • Marien P. Dekker
    • Leendert W. Hamoen
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13