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Showing 1–7 of 7 results

Advanced filters: Author: Leigh Goedeke Clear advanced filters

Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis

A role and mechanism of action are identified for INSP3R1 in the stimulation of hepatic gluconeogenesis and mitochondrial oxidation by glucagon, suggesting that INSP3R1 may be a target for ameliorating dysregulation of hepatic glucose metabolism.

Rachel J. Perry
Dongyan Zhang
Gerald I. Shulman
Research04 Mar 2020
Nature

Volume: 579, P: 279-283
Mammary duct luminal epithelium controls adipocyte thermogenic programme

In mice, sympathetic nerves associated with female mammary glands control the secretion of thermogenesis-controlling factors by epithelial cells in the adipocyte niche, revealing sex-specific differences in adipose thermogenesis.

Sanil Patel
Njeri Z. R. Sparman
Prashant Rajbhandari
Research26 Jul 2023
Nature

Volume: 620, P: 192-199
Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake

Insulin stimulates TUG cleavage to translocate GLUT4 and enhance glucose uptake. Here Bogan and colleagues show that the TUG cleavage product regulates thermogenic gene transcription, thereby coupling glucose uptake to organismal energy expenditure.

Estifanos N. Habtemichael
Don T. Li
Jonathan S. Bogan
Research08 Mar 2021
Nature Metabolism

Volume: 3, P: 378-393
MMAB promotes negative feedback control of cholesterol homeostasis

The mechanisms governing cholesterol homeostasis remain incompletely understood. Here, the authors develop an integrative genomic strategy to identify MMAB, and enzyme in the adenosylcobalamin pathway, as a regulator of hepatic LDLR activity and cholesterol biosynthesis.

Leigh Goedeke
Alberto Canfrán-Duque
Carlos Fernández-Hernando
ResearchOpen Access08 Nov 2021
Nature Communications

Volume: 12, P: 1-18
Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis

From a systematic analysis of genome-wide association studies of blood lipid levels, Wagschal et al. identify several miRNAs that target key proteins involved in cholesterol and lipid metabolism, including the LDL receptor and the ABCA1 cholesterol transporter.

Alexandre Wagschal
S Hani Najafi-Shoushtari
Anders M Näär
Research26 Oct 2015
Nature Medicine

Volume: 21, P: 1290-1297
MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels

MicroRNA-148a, whose expression is regulated by the transcription factor SREBP1c, controls LDL and HDL metabolism through direct targeting of the genes encoding the LDL receptor and the cholesterol transporter ABCA1.

Leigh Goedeke
Noemi Rotllan
Carlos Fernández-Hernando
Research05 Oct 2015
Nature Medicine

Volume: 21, P: 1280-1289
Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides

Katey J. Rayner
Christine C. Esau
Kathryn J. Moore
Research19 Oct 2011
Nature

Volume: 478, P: 404-407