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Showing 1–25 of 25 results
Advanced filters: Author: Leighton O. Jones Clear advanced filters
    • GARTH J. S. COOPER
    • ANTHONY C. WILLIS
    • BRENDAN LEIGHTON
    Research
    Nature
    Volume: 340, P: 272
  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768
  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477
  • Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

    • Steven A. Kemp
    • Dami A. Collier
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 592, P: 277-282
  • Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

    • Dami A. Collier
    • Anna De Marco
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 593, P: 136-141
  • Eco-friendly, efficient, and selective gold recovery technologies are urgently desired to satisfy the increasing demand for gold. Here, the authors report one such technology based on the supramolecular polymerization of second-sphere coordinated adducts formed between β-cyclodextrin and tetrabromoaurate anions.

    • Huang Wu
    • Yu Wang
    • J. Fraser Stoddart
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11
  • A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

    • Harald S. Vöhringer
    • Theo Sanderson
    • Moritz Gerstung
    ResearchOpen Access
    Nature
    Volume: 600, P: 506-511
  • A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

    • Antonia Ho
    • Richard Orton
    • Emma C. Thomson
    Research
    Nature
    Volume: 617, P: 555-563
  • Although pyrene-containing molecules have been studied for their optical properties, the outcome of their incorporation into mechanically interlocked structures remains underexplored. Here, the authors install pyrene units into homo[2]catenanes and investigate the formation of long-lived triplet states, which can be exploited for photocatalysis.

    • Amine Garci
    • Jacob A. Weber
    • J. Fraser Stoddart
    Research
    Nature Catalysis
    Volume: 5, P: 524-533
  • Encapsulating large and contorted nanographenes inside artificial receptors remain challenging. This work reports the synthesis, characterization and binding properties of a trigonal prismatic cage compound that can serve as a receptor for contorted nanographene derivatives.

    • Huang Wu
    • Yu Wang
    • J. Fraser Stoddart
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13
  • Two-photon excited near-infrared fluorescence materials have garnered considerable attention because of their superior optical properties compared with other optical materials. Here, the authors use a convenient and efficient supramolecular approach to synthesize a two-photon excited near-infrared emissive co-crystalline material.

    • Yu Wang
    • Huang Wu
    • J. Fraser Stoddart
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11
  • Synaptic activity controls the extinction of conditioned fear. Here the authors discovered a new way that the brain controls memories of fear: a long noncoding RNA called Gas5 that coordinates the activity of RNA granules in the synaptic compartment.

    • Wei-Siang Liau
    • Qiongyi Zhao
    • Timothy W. Bredy
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16
  • Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

    • Heather J. Cordell
    • Younghun Han
    • Katherine A. Siminovitch
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11
  • Focusing on two ill-characterized subtypes of medulloblastoma (group 3 and group 4), this study identifies prevalent genomic structural variants that are restricted to these two subtypes and independently bring together coding regions of GFI1 family proto-oncogenes with active enhancer elements, leading to their mutually exclusive oncogenic activation.

    • Paul A. Northcott
    • Catherine Lee
    • Stefan M. Pfister
    Research
    Nature
    Volume: 511, P: 428-434
  • Phytophthora infestans is a fungus-like eukaryote and the most destructive pathogen of potato, with current annual worldwide potato crop losses due to late blight estimated at $6.7 billion. Here, the sequence of the P. infestans genome is reported. Comparison with two other Phytophthora genomes showed rapid turnover and extensive expansion of certain secreted disease effector proteins, probably explaining the rapid adaptability of the pathogen to host plants.

    • Brian J. Haas
    • Sophien Kamoun
    • Chad Nusbaum
    ResearchOpen Access
    Nature
    Volume: 461, P: 393-398
  • Analysis of changes in functional groups of species and potential drivers of environmental change for protected areas across the world’s major tropical regions reveals large variation between reserves that have been effective and those experiencing an erosion of biodiversity, and shows that environmental changes immediately outside reserves are nearly as important as those inside in determining their ecological fate.

    • William F. Laurance
    • D. Carolina Useche
    • Franky Zamzani
    Research
    Nature
    Volume: 489, P: 290-294
  • The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

    • Jesse M. Engreitz
    • Heather A. Lawson
    • Ella K. Samer
    Reviews
    Nature
    Volume: 633, P: 47-57