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Showing 1–3 of 3 results
Advanced filters: Author: Lemlem Alemu Clear advanced filters

  • VEXAS syndrome is a clinically heterogeneous inflammatory condition caused by mutations in the UBA1 gene. Here, by single cell transcriptomics on peripheral blood cells from VEXAS patients, the authors reveal innate and adaptive immune dysregulations irrespective of UBA1 mutations, including the presence of functionally impaired monocytes and clonal expansion of UBA1 wild-type effector memory B cells and plasmablasts.

    • Hiroki Mizumaki
    • Shouguo Gao
    • Bhavisha A. Patel
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • The transcriptional phenotype of immune cells associated with severe aplastic anaemia (SAA) may change post immunotherapy. Here the authors analyse single cell transcriptomics of hematopoietic and immune cells from SAA patients and assess how these phenotypes change after treatment showing alterations in myeloid cells and TCR clonal abundance correlate with robustness of hematopoietic response.

    • Zhijie Wu
    • Shouguo Gao
    • Neal S. Young
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21

  • T cell large granular lymphocyte leukemia (T-LGLL) and the cellular phenotype underlying response to therapy is not well understood. Here the authors use single cell sequencing to better understand changes in T cell clonal frequency and gene expression before and after therapy in T-LGLL.

    • Shouguo Gao
    • Zhijie Wu
    • Neal S. Young
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14