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Showing 1–3 of 3 results
Advanced filters: Author: Lena Kobel Clear advanced filters

  • Inhibitors of the protein kinase Wee1 are promising drugs for cancer therapy. Here, the authors show that these drugs activate the integrated stress response via GCN2, synergising with mRNA translation defects. They suggest strategies such as PROTACs or ISR inhibitors to improve WEE1 mediated toxicity.

    • Jordan C. J. Wilson
    • JiaYi Zhu
    • Stephen P. Jackson
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • CRISPR-Cas induced HDR methods tend to have a low efficiency. Here the authors report an HDR improvement strategy, Recursive Editing, that selectively retargets undesired indel outcomes to create additional opportunities for HDR; they introduce REtarget, a tool for Recursive Editing experimental design.

    • Lukas Möller
    • Eric J. Aird
    • Jacob E. Corn
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Combinatorial CRISPRi screening was used to map genetic interactions in DNA damage response pathways, revealing known and new connections, including the roles of WDR48 and USP1 in preventing under-replication and SMARCAL1 and FANCM in remodelling persistent cruciform DNA structures.

    • John Fielden
    • Sebastian M. Siegner
    • Jacob E. Corn
    ResearchOpen Access
    Nature
    Volume: 640, P: 1093-1102