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Showing 1–3 of 3 results
Advanced filters: Author: Lena N. Mangels Clear advanced filters

  • The Src-homology 3 domain of phosphatidyl-inositol-3-kinase (PI3K-SH3) is a model system for studying amyloid fibril formation. Here the authors present the 3.4 Å cryo-EM structure of the PI3K-SH3 amyloid fibril, which allows them to rationalize the effects of mutations on the kinetics of fibril formation.

    • Christine Röder
    • Nicola Vettore
    • Gunnar F. Schröder
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • Many ecological studies assume that space-for-time substitution approaches can be suitable proxies for unavailable time series. Here the authors show congruence between the two approaches in the direction but not the magnitude of grassland plant and arthropod community responses to land-use intensification.

    • L. Neuenkamp
    • H. Saiz
    • C. Penone
    Research
    Nature Ecology & Evolution
    Volume: 9, P: 2290-2303

  • Amyloid fibrils grow through the recruitment of soluble monomer to the fibril end that propagates the fibril structure. Here the transition state, the rate-limiting conformation, of such a reaction has been characterized by Φ-value analysis. An energy landscape model has been developed and fibril growth rates predicted from first principles.

    • Jacob Aunstrup Larsen
    • Abigail Barclay
    • Alexander K. Buell
    Research
    Nature Chemistry
    Volume: 17, P: 403-411