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Showing 1–5 of 5 results
Advanced filters: Author: Lenka Faltova Clear advanced filters

  • Open compartments, termed biomolecular condensates, are involved in cellular reactions. This Comment highlights their ability to enhance robustness and control of reactions in space and time, going beyond mere acceleration or inhibition. They enable reaction engineering at the mesoscale, not just by altering concentrations but also by modifying the local environment.

    • Marcell Papp
    • Florence Stoffel
    • Paolo Arosio
    Comments & Opinion
    Nature Chemical Engineering
    Volume: 2, P: 394-397

  • The underlying mechanism for how heterotypic protein–RNA interactions modulate the liquid to amyloid transition of hnRNPA1A, a protein involved in amyotrophic lateral sclerosis, has so far remained elusive. Now characterization of hnRNPA1A condensate formation and aggregation in vitro reveals that the RNA/protein stoichiometry affects the molecular pathways leading to amyloid formation.

    • Chiara Morelli
    • Lenka Faltova
    • Paolo Arosio
    ResearchOpen Access
    Nature Chemistry
    Volume: 16, P: 1052-1061

  • Understanding of the molecular mechanisms underlying the maturation of protein condensates into amyloid fibrils associated with neurodegenerative diseases has so far remained elusive. Now it has been shown that in condensates formed by the low-complexity domain of the amyotrophic lateral sclerosis-associated protein hnRNPA1, fibril formation is promoted at the interface, which provides a potential therapeutic target for counteracting aberrant protein aggregation.

    • Miriam Linsenmeier
    • Lenka Faltova
    • Paolo Arosio
    ResearchOpen Access
    Nature Chemistry
    Volume: 15, P: 1340-1349