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Within-host genetic diversity of SARS-CoV-2 lineages in unvaccinated and vaccinated individuals

There is limited data on within-host SARS-CoV-2 genetic diversity and how it is affected by vaccination. The authors analysed intra-host sequence diversity and found that VOCs may have more sequence variations than non-VOCs and that breakthrough infections in vaccinated individuals do not seem to increase non-silent mutations.

Haogao Gu
Ahmed Abdul Quadeer
Leo L. M. Poon
ResearchOpen Access31 Mar 2023
Nature Communications

Volume: 14, P: 1-14
SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults

The molecular basis for differences in immune response to SARS-CoV-2 in children and adults is still unclear. Here, the authors show that antibodies are of high binding and functional quality in children with mild or asymptomatic infection, but antibody response is delayed as compared to adults.

Carolyn A. Cohen
Ludivine Grzelak
Sophie A. Valkenburg
ResearchOpen Access23 Aug 2025
Nature Communications

Volume: 16, P: 1-14
Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

WL Blalock
C Weinstein-Oppenheimer
JA McCubrey
Reviews09 Aug 1999
Leukemia

Volume: 13, P: 1109-1166

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