Nature Search

Pre-existing and early cellular immune factors correlate with functionally complete protection against primary controlled human SARS-CoV-2 infection

Human challenge studies with SARS-CoV-2 have shown changes in the innate and adaptive immune response. Here the authors are examining potential correlates of infection in virus challenged recipients by assessing baseline immune parameters and how this predicts virus control.

Helen R. Wagstaffe
Ryan S. Thwaites
Christopher Chiu
ResearchOpen Access07 Dec 2025
Nature Communications

Volume: 17, P: 1-15
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

Seronegative healthcare workers with an innate signature of infection preferentially expand pre-existing T cells targeting the conserved replication transcription complex of SARS-CoV-2 in abortive infection.

Leo Swadling
Mariana O. Diniz
Mala K. Maini
ResearchOpen Access10 Nov 2021
Nature

Volume: 601, P: 110-117
Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity

Authors utilise a cohort of healthcare workers, infected during the first wave of the SARS-CoV-2 pandemic, to assess symptom persistence and humoral and cellular immunity.

Daniel M. Altmann
Catherine J. Reynolds
Rosemary J. Boyton
ResearchOpen Access23 Aug 2023
Nature Communications

Volume: 14, P: 1-9
A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection

A liver-intrinsic mechanism is presented that suppresses effective anti-hepatitis virus B responses in mice and humans by rendering virus-specific CD8 T cells refractory to activation causing loss of effector functions.

Miriam Bosch
Nina Kallin
Percy A. Knolle
ResearchOpen Access10 Jul 2024
Nature

Volume: 631, P: 867-875
Human SARS-CoV-2 challenge uncovers local and systemic response dynamics

A human SARS-CoV-2 challenge study in individuals without previous exposure to the virus or vaccines provides detailed profiles of local and systemic epithelial and immune cell response dynamics over time and infection status.

Rik G. H. Lindeboom
Kaylee B. Worlock
Sarah A. Teichmann
ResearchOpen Access19 Jun 2024
Nature

Volume: 631, P: 189-198
Tissue CD14⁺CD8⁺ T cells reprogrammed by myeloid cells and modulated by LPS

Bacterial products in the gut–liver axis and tissue stromal factors can tune liver immunity by driving myeloid instruction of CD8⁺ T cells with immunomodulatory ability.

Laura J. Pallett
Leo Swadling
Mala K. Maini
Research25 Jan 2023
Nature

Volume: 614, P: 334-342
Author Correction: Human SARS-CoV-2 challenge uncovers local and systemic response dynamics

Rik G. H. Lindeboom
Kaylee B. Worlock
Sarah A. Teichmann
Amendments and CorrectionsOpen Access01 Aug 2024
Nature

Volume: 632, P: E3
Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma

Many cancer immune therapy approaches depend on an HLA-restricted neoantigen-specific T cell response. AUs show here that Zoledronic acid can expand, and induce tumour recognition by, a population of tissue resident memory gamma-delta T cells associated with an efficient anti-tumour immune response in hepatocellular carcinoma.

Nekisa Zakeri
Andrew Hall
Mala K. Maini
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-16
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint

Shared metabolic pathways could allow simultaneous manipulation of T cells, viruses and tumours. Here the authors show targeting cholesterol esterification restrains hepatitis B in vitro, whilst bolstering exhausted antigen-specific T cell responses from human liver and hepatocellular carcinoma.

Nathalie M. Schmidt
Peter A. C. Wing
Mala K. Maini
ResearchOpen Access14 May 2021
Nature Communications

Volume: 12, P: 1-14
Optimising T cell (re)boosting strategies for adenoviral and modified vaccinia Ankara vaccine regimens in humans

Stefania Capone
Anthony Brown
Leo Swadling
ResearchOpen Access12 Oct 2020
npj Vaccines

Volume: 5, P: 1-14
T cells in COVID-19 — united in diversity

Comprehensive mapping reveals that functional CD4⁺ and CD8⁺ T cells targeting multiple regions of SARS-CoV-2 are maintained in the resolution phase of both mild and severe COVID-19, and their magnitude correlates with the antibody response.

Leo Swadling
Mala K. Maini
News & Views07 Sept 2020
Nature Immunology

Volume: 21, P: 1307-1308
Airway-resident T cells from unexposed individuals cross-recognize SARS-CoV-2

Maini and colleagues used bronchoalveolar lavage (BAL) samples from the lower respiratory tract of healthy donors obtained before the COVID-19 pandemic to show airway-resident cross-reactive T cells are present in pre-pandemic BAL, and correlated with the strength of human coronavirus immunity

Mariana O. Diniz
Elena Mitsi
Mala K. Maini
ResearchOpen Access29 Aug 2022
Nature Immunology

Volume: 23, P: 1324-1329
Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing

Jonathan Flint, Richard Mott and colleagues employ low-coverage (0.15×) sequencing and their new imputation method STITCH to perform genome-wide association analysis for complex traits in an outbred mouse population. They find >250 QTLs for 92 phenotypes and obtain gene-level mapping resolution for around 20% of the loci.

Jérôme Nicod
Robert W Davies
Jonathan Flint
Research04 Jul 2016
Nature Genetics

Volume: 48, P: 912-918

Search

Filter By:

Search

Quick links