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Showing 1–2 of 2 results
Advanced filters: Author: Leonardo Feletto Clear advanced filters

  • Here, the authors determine the structural basis of how SGO1 protects centromeric cohesin from WAPL-mediated release until the kinetochores and the microtubules have formed functional attachments. In addition, they show that SGO1 and CTCF bind cohesin in a similar manner, suggesting a potential universal mechanism of cohesin control.

    • Alberto García-Nieto
    • Amrita Patel
    • Benjamin D. Rowland
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 853-859

  • Here the authors use structural analyses to show that an intrinsically disordered transcription activation domain in the oncogene BRD4-NUT binds to and activates p300. This in-turn drives formation of higher-order, acetylation-dependent chromatin condensates.

    • Ziad Ibrahim
    • Tao Wang
    • Daniel Panne
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-23