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Showing 1–9 of 9 results
Advanced filters: Author: Leonardo Morsut Clear advanced filters

  • A major goal in synthetic development is to build gene regulatory circuits that control patterning. Here the authors discover that elevated cell density dampens SynNotch signaling, enabling the design of density-dependent synNotch patterning circuits where multicellular patterning outcomes are programmed by controlled cell proliferation in time and space.

    • Marco Santorelli
    • Pranav S. Bhamidipati
    • Leonardo Morsut
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-22

  • Synthetic Notch (synNotch) receptors are genetically encoded, modular synthetic receptors that enable mammalian cells to detect environmental signals and respond by activating user-prescribed transcriptional programs. Here the authors apply synNotch receptors to spatially control differentiation of endothelial and skeletal muscle cells in a multicellular construct on assorted biomaterials.

    • Mher Garibyan
    • Tyler Hoffman
    • Leonardo Morsut
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • Understanding of fundamental questions in human embryology is hampered by limited access to in utero developmental events. Manfrin et al. have engineered an in vitro platform that recapitulates early morphogenic events of human development with unprecedented spatial and temporal control.

    • Leonardo Morsut
    • Giorgia Quadrato
    News & Views
    Nature Methods
    Volume: 16, P: 585-586

  • Generation of the organizer tissue is induced on the dorsal side of the developing embryo by an asymmetry in Nodal signalling, which is only sufficiently high dorsally to induce organizer-specific gene expression. Now, through the identification of a microRNA (miR-15 and miR-16) that targets the Nodal receptor, microRNA is shown to have a role in this process.

    • Graziano Martello
    • Luca Zacchigna
    • Stefano Piccolo
    Research
    Nature
    Volume: 449, P: 183-188

  • Synthetic receptor signaling systems have evolved as platforms for user-controlled programming of cellular functions. This Perspective reviews these advances and defines a metrics-based engineering workflow to support future engineering efforts.

    • Janvie Manhas
    • Hailey I. Edelstein
    • Leonardo Morsut
    Reviews
    Nature Chemical Biology
    Volume: 18, P: 244-255

  • In the TGFβ pathway, receptor-activated SMADs (R-SMADs) associate with SMAD4 to regulate transcription. Piccolo and colleagues reveal that the deubiquitylase USP15 is required for TGFβ responses by reversing R-SMAD ubiquitylation and thereby promoting the retention of the SMAD complex at promoters.

    • Masafumi Inui
    • Andrea Manfrin
    • Stefano Piccolo
    Research
    Nature Cell Biology
    Volume: 13, P: 1368-1375

  • This Perspective reviews the complementary developments in synthetic biology and biomaterials and discusses how convergence of these two fields creates a promising design strategy for the fabrication of tailored living materials for medicine and biotechnology.

    • Allen P. Liu
    • Eric A. Appel
    • Ovijit Chaudhuri
    Reviews
    Nature Materials
    Volume: 21, P: 390-397