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Showing 1–6 of 6 results
Advanced filters: Author: Leonid Minakhin Clear advanced filters

  • Here the authors reveal a two-step spatiotemporal regulation of (Polθ)-mediated end-joining (TMEJ). First, PARP1 PARylates Polθ and facilitates its recruitment to the vicinity of DNA damage sites in an inactivated state. PARG subsequently activates TMEJ by removing repressive PAR marks on Polθ.

    • Umeshkumar Vekariya
    • Leonid Minakhin
    • Tomasz Skorski
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • DNA polymerase theta (Polθ) plays central roles in microhomology-mediated end joining (MMEJ) DNA damage repair. Here, the authors determine a series of structures of Polθ helicase domain during the MMEJ, revealing key conformational changes for DNA binding, microhomology search, and annealing.

    • Fumiaki Ito
    • Ziyuan Li
    • Xiaojiang S. Chen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Polθ helicase is crucial for DNA repair and a target for precision medicine for cancer therapy. Here, the authors reveal the mechanism of action of the small-molecule inhibitor AB25583, and show its high specificity and selective killing of BRCA1/2– cancer cells and synergy with olaparib.

    • Fumiaki Ito
    • Ziyuan Li
    • Richard T. Pomerantz
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • The RNA polymerase from the crAss-like bacteriophage phi14:2, which is translocated into the host cell with phage DNA and transcribes early phage genes, is structurally most similar to eukaryotic RNA interference polymerases, suggesting that the latter have a phage origin.

    • Arina V. Drobysheva
    • Sofia A. Panafidina
    • Maria L. Sokolova
    Research
    Nature
    Volume: 589, P: 306-309