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Showing 1–4 of 4 results
Advanced filters: Author: Leonid Yurkovetskiy Clear advanced filters

  • Androgen is a sex hormone that may contribute to sex biases in autoimmunity. Here the authors show that in T cells androgen induces the expression of Ptpn22 phosphatase to negatively regulate T cell activation, thereby contributing to protecting males from major autoimmune diseases such as systemic lupus erythematosus and type 1 diabetes.

    • Jean Lee
    • Leonid A. Yurkovetskiy
    • Alexander V. Chervonsky
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • During HIV infection, antiviral therapy can suppress viraemia to undetectable levels and hinder the progression towards AIDS; however the HIV-1 provirus can remain in long-lived CD4+ memory T cells. Here the authors show that intronic RNA from the HIV-1 provirus can induce type I interferon and inflammatory cytokine production.

    • Sean Matthew McCauley
    • Kyusik Kim
    • Jeremy Luban
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • This study answers the long-standing question of why the interaction between cyclophilin A (CypA) and HIV-1 capsid (CA) protein stimulates HIV-1 infectivity in human cells. Disruption of the CA−CypA interaction renders HIV-1 susceptible to potent restriction by human TRIM5α in primary blood cells, which occurs before reverse transcription.

    • Kyusik Kim
    • Ann Dauphin
    • Jeremy Luban
    Research
    Nature Microbiology
    Volume: 4, P: 2044-2051