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Showing 1–8 of 8 results
Advanced filters: Author: Leonie Ringrose Clear advanced filters

  • Leonie Ringrose highlights how mathematical modelling can provide insights into fundamental mechanisms underlying epigenetic regulation.

    • Leonie Ringrose
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 642

  • Leonie Ringrose and colleagues show that a switch between forward and reverse noncoding transcription at the Drosophila melanogaster vestigial Polycomb/Trithorax response element switches the status of the element between silencing and activation. They further show that strand switching of noncoding RNAs occurs at several hundred PcG-binding sites in flies and vertebrates, suggesting that this regulatory mechanism could be widespread.

    • Veronika A Herzog
    • Adelheid Lempradl
    • Leonie Ringrose
    Research
    Nature Genetics
    Volume: 46, P: 973-981

  • Polycomb and Trithorax group proteins regulate silent and active gene expression states, but also allow poised states in pluripotent cells. Here the authors present a mathematical model that integrates data on Polycomb/ Trithorax biochemistry into a single coherent framework which predicts that poised chromatin is not bivalent as previously proposed, but is bistable, meaning that the system switches frequently between stable active and silent states.

    • Kim Sneppen
    • Leonie Ringrose
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18

  • Epigenetic memory maintains gene expression states through cell generations, in the absence of the initiating signals or changes in DNA sequence. Our understanding of how the Polycomb (PcG) and Trithorax (TrxG) group proteins confer long-term, mitotically heritable memory by sustaining silent and active gene expression states, respectively, during DNA replication and mitosis, is increasing.

    • Philipp A. Steffen
    • Leonie Ringrose
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 15, P: 340-356

  • Polycomb (PcG) and Trithorax (TrxG) group regulate several hundred target genes with important roles in development and disease. Here the authors combine experiment and theory to provide evidence that the Polycomb/Trithorax system has the potential for a rich repertoire of regulatory modes beyond simple epigenetic memory.

    • Jeannette Reinig
    • Frank Ruge
    • Leonie Ringrose
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • The cell-division cycle involves careful timing: cell-cycle genes must be switched on only when needed. The retinoblastoma protein controls one set of these genes, and one way it does this is most unusual.

    • Leonie Ringrose
    • Renato Paro
    News & Views
    Nature
    Volume: 412, P: 493-494

  • The recent rise in obesity and its associated diseases has sparked intensive research into the transcriptional control of metabolic processes, collectively termed energy homeostasis. The authors review our current understanding of transcriptional and epigenetic regulators of energy homeostasis and crosstalk between pathways, and provide insights into emerging developments and challenges in this field.

    • Adelheid Lempradl
    • J. Andrew Pospisilik
    • Josef M. Penninger
    Reviews
    Nature Reviews Genetics
    Volume: 16, P: 665-681