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Showing 1–12 of 12 results
Advanced filters: Author: Leonora Balaj Clear advanced filters

  • Efficient and non-invasive, liquid biopsy methods could greatly improve the molecular classification of gliomas. Here, the authors develop an RNA-based Droplet Digital PCR assay to detect the key IDH1.R132H mutation in plasma-derived extracellular vesicles from glioma patients with high sensitivity, allowing accurate diagnosis, prognostication and longitudinal monitoring.

    • Syeda Maheen Batool
    • Ana K. Escobedo
    • Bob S. Carter
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Microvesicles containing RNA are released from tumour cells. Here, the authors show that microvesicles released from tumour cells in culture have amplified levels of thec-Myconcogene, which is also found in the cell of origin, suggesting that microvesicles could be used as biomarkers.

    • Leonora Balaj
    • Ryan Lessard
    • Johan Skog
    Research
    Nature Communications
    Volume: 2, P: 1-9

  • Predicting and monitoring chemotherapy response remains a challenge for glioma treatment. Here the authors show that a microfluidic device can isolate glioma-derived exosomes from patient blood and accurately determine the levels of mRNA of key enzymes important for chemoresponsiveness.

    • Huilin Shao
    • Jaehoon Chung
    • Ralph Weissleder
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • Patients with myotonic dystrophy need to undergo invasive muscle biopsies to monitor disease progression and response to therapy. Here, the authors show that extracellular RNAs in human urine can be used as biomarkers to differentiate patients from unaffected controls, and to monitor exon skipping in patients with Duchenne muscular dystrophy taking the drug eteplirsen.

    • Layal Antoury
    • Ningyan Hu
    • Thurman M. Wheeler
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • Extracellular vesicles can carry many different types of biological cargo and have been investigated as a biomarker for cancer diagnosis. Here the authors develop a microfluidic platform for rapid and sensitive isolation of tumor-specific extracellular vesicles.

    • Eduardo Reátegui
    • Kristan E. van der Vos
    • Shannon L. Stott
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • This Review describes the state of the art in imaging extracellular vesicles in animals to study their release, biodistribution and uptake, and covers labeling strategies, microscopy methods and discoveries made in model organisms.

    • Frederik J. Verweij
    • Leonora Balaj
    • Guillaume van Niel
    Reviews
    Nature Methods
    Volume: 18, P: 1013-1026

  • While circulating DNA has been extensively explored as a potential cancer biomarker, RNA potential has been overlooked so far. Here the authors present a comprehensive analysis of extracellular RNA secreted by glioblastoma cells that could prove a valuable resource for biomarker discovery and a means of intercellular communication.

    • Zhiyun Wei
    • Arsen O. Batagov
    • Anna M. Krichevsky
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • Single-cell RNAseq during initiation and progression of mouse glioblastoma reveals a dynamic immune microenvironment transitioning from pro-inflammatory microglia in early tumors towards an infiltrating macrophage and suppressor cell-centric immune landscape in late-stage tumors.

    • Alan T. Yeo
    • Shruti Rawal
    • Al Charest
    ResearchOpen Access
    Nature Immunology
    Volume: 23, P: 971-984

  • Cancer cells shed large numbers of small, membrane-bound microvesicles (MVs) into the circulation, which have diagnostic potential but have proved difficult to analyze in a point-of-care setting. Huilin Shao and colleagues have developed a microfluidic chip with an integrated NMR detection system for the rapid profiling of circulating MVs directly from blood samples of patients with glioblastoma. The system was used to distinguish cancer cell–derived MVs from host cell–derived MVs and to measure treatment effects in vivo.

    • Huilin Shao
    • Jaehoon Chung
    • Hakho Lee
    Research
    Nature Medicine
    Volume: 18, P: 1835-1840