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Scientific Reports (2)
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Showing 1–4 of 4 results

Advanced filters: Author: Lesley A. Colgan Clear advanced filters

PKCα integrates spatiotemporally distinct Ca²⁺ and autocrine BDNF signaling to facilitate synaptic plasticity

Through the development of novel PKC biosensors, the authors describe how PKCα, but not other classical isozymes, facilitates plasticity in dendritic regions through the integration of recent synaptic plasticity with current, local synaptic input.

Lesley A Colgan
Mo Hu
Ryohei Yasuda
Research16 Jul 2018
Nature Neuroscience

Volume: 21, P: 1027-1037
Rac1 is a downstream effector of PKCα in structural synaptic plasticity

Xun Tu
Ryohei Yasuda
Lesley A. Colgan
ResearchOpen Access04 Feb 2020
Scientific Reports

Volume: 10, P: 1-9
Precise small-molecule recognition of a toxic CUG RNA repeat expansion

Dimeric bis-benzimidazole compounds that bind selectively to toxic expanded r(CUG) RNA repeat sequences were identified and used as a scaffold for covalent modification, site-specific cleavage and on-target assembly of imaging reagents at expanded r(CUG) sequences in cells.

Suzanne G Rzuczek
Lesley A Colgan
Matthew D Disney
Research12 Dec 2016
Nature Chemical Biology

Volume: 13, P: 188-193
Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores

Donogh Maguire
Alana Burns
Donald C. McMillan
ResearchOpen Access28 Apr 2022
Scientific Reports

Volume: 12, P: 1-18