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Showing 1–7 of 7 results
Advanced filters: Author: Lesley A. Inker Clear advanced filters

  • In a meta-analysis of 48 randomized trials of chronic kidney disease progression, reduction in the 6-month urinary albumin:creatinine ratio was associated with lower hazard ratios of established kidney disease endpoints, supporting the use of albuminuria change as a surrogate endpoint in clinical trials for chronic kidney disease.

    • Hiddo J. L. Heerspink
    • Willem H. Collier
    • Lesley A. Inker
    Research
    Nature Medicine
    Volume: 32, P: 281-287

  • A meta-analysis of individual-level patient data from 66 clinical studies supports the utility of glomerular filtration rate as a surrogate endpoint in clinical trials for chronic kidney disease, with potential to enable detection of events earlier in the disease course.

    • Lesley A. Inker
    • Willem Collier
    • Mauro Saddelli
    Research
    Nature Medicine
    Volume: 29, P: 1867-1876

  • Patients with chronic kidney disease often require complex polypharmacy, require dose adjustments or discontinuation with changes in kidney function, and can be susceptible to the adverse effects of medications. This Review discusses the principles of drug stewardship — that is, the effective, safe and sustainable use of medications — for people with chronic kidney disease.

    • Rasheeda K. Hall
    • Rümeyza Kazancıoğlu
    • Juan J. Carrero
    Reviews
    Nature Reviews Nephrology
    Volume: 20, P: 386-401

  • The authors of this Perspectives article describe the physiological and statistical principles underlying measured glomerular filtration rate (mGFR) and estimated glomerular filtration rate (eGFR). They discuss their limitations, the circumstances under which mGFR and eGFR should be used, and approaches to improve these methodologies.

    • Andrew S. Levey
    • Josef Coresh
    • Lesley A. Inker
    Reviews
    Nature Reviews Nephrology
    Volume: 16, P: 51-64