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Showing 1–4 of 4 results
Advanced filters: Author: Lesley T. MacNeil Clear advanced filters

  • In the worm, netrin and the TGFβ-related molecule UNC-129 form opposing dorsoventral gradients. Motor axons are repelled by netrin and attracted to UNC-129, but no TGFβ receptors appear to be involved in the attraction. This study shows that UNC-129 enhances repulsive signaling from the netrin receptor complex UNC-5/UNC-40, via a direct interaction with UNC-5.

    • Lesley T MacNeil
    • W Rod Hardy
    • Joseph G Culotti
    Research
    Nature Neuroscience
    Volume: 12, P: 150-155

  • Frank Costantini and colleagues report the identification of the ETS transcription factors, Etv4 and Etv5, as key targets of Ret signaling during kidney branching morphogenesis. Loss of Etv4 and Etv5 function in mice leads to complete failure of kidney development.

    • Benson C Lu
    • Cristina Cebrian
    • Frank Costantini
    Research
    Nature Genetics
    Volume: 41, P: 1295-1302

  • Metformin is the mainstay therapy for type 2 diabetes mellitus. A new study shows that metformin acts directly on gut bacteria to elevate cAMP-induced agmatine production, thereby increasing lipid metabolism and lifespan in model organisms. These data identify links between metformin and gut microbiota that might be important for increasing longevity.

    • Lesley T. MacNeil
    • Jonathan D. Schertzer
    • Gregory R. Steinberg
    News & Views
    Nature Reviews Endocrinology
    Volume: 16, P: 9-10