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Showing 1–4 of 4 results
Advanced filters: Author: Lesley Vanes Clear advanced filters

  • T cell antigen receptor stimulation by the ligand antigen triggers multiple downstream pathways that affect CD4 + T cell function. Here authors show that activation of the downstream WNK1 kinase causes water entry into the cells, which is essential for CD4+ T cell proliferation.

    • Joshua Biggs O’May
    • Lesley Vanes
    • Victor L. J. Tybulewicz
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • The ability of T cells to migrate is a central component of their functionality and is known to require WNK1 kinase that is linked to the influx of ions into the cell. Here the authors show that T cell migration requires WNK1 mediated ion and water influx to swell the membrane of the leading edge and support actin polymerisation and forward motility.

    • Leonard L. de Boer
    • Lesley Vanes
    • Victor L. J. Tybulewicz
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • The kinase WNK1 is part of a pathway that controls the uptake of ions into kidney cells. Tybulewicz and colleagues show that a related pathway involving WNK1 also operates in T cells, in which it negatively regulates adhesion and positively regulates migration.

    • Robert Köchl
    • Flavian Thelen
    • Victor L J Tybulewicz
    Research
    Nature Immunology
    Volume: 17, P: 1075-1083