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Showing 1–3 of 3 results
Advanced filters: Author: Leslie A. Nangle Clear advanced filters

  • tRNA synthetases (RSs) have been implicated in functions beyond tRNA synthesis, and human TrpRS has been implicated in inhibiting angiogenesis. Tryptophan residues implicated in homotypic interactions on VE-cadherin are now shown to bind the active site of a naturally truncated TrpRS, indicating how this enzyme has been repurposed.

    • Quansheng Zhou
    • Mili Kapoor
    • Xiang-Lei Yang
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 57-61

  • In mice with the sticky mutation, the cells that are involved in motor coordination degenerate, due to a single nucleotide change in the enzyme called alanyl-tRNA synthetase. This demonstrates the potentially catastrophic consequences of small changes in the fidelity of translation.

    • Jeong Woong Lee
    • Kirk Beebe
    • Susan L. Ackerman
    Research
    Nature
    Volume: 443, P: 50-55