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The HEAT repeat protein HPO-27 is a lysosome fission factor

The conserved HEAT repeat protein HPO-27 is identified as a lysosome scission factor in Caenorhabditis elegans, and the human homologue MROH1 also serves the same function to maintain lysosomal homeostasis.

Letao Li
Xilu Liu
Xiaochen Wang
Research27 Mar 2024
Nature

Volume: 628, P: 630-638
High-entropy engineered BaTiO₃-based ceramic capacitors with greatly enhanced high-temperature energy storage performance

The authors utilize a high-entropy design strategy to enhance the high-temperature energy storage capabilities of BaTiO₃-based ceramic capacitors, realizing energy storage performance from −50 °C to 260 °C and maintaining functionality after one million charge-discharge cycles at 200 °C.

Xi Kong
Letao Yang
Ce-Wen Nan
ResearchOpen Access21 Jan 2025
Nature Communications

Volume: 16, P: 1-9
Engineering relaxors by entropy for high energy storage performance

Dielectric capacitors based on relaxor ferroelectrics are a promising energy storage technology, and an efficient design of relaxors is useful to enhance the storage performance. Here the authors quantitatively evaluate the local compositional inhomogeneity of relaxors via a configurational entropy index and realize overall high performance in a Bi₄Ti₃O₁₂-based device.

Bingbing Yang
Qinghua Zhang
Yuan-Hua Lin
Research10 Jul 2023
Nature Energy

Volume: 8, P: 956-964
Design of stimuli-responsive minimalist heptad surfactants for stable emulsions

Peptide surfactants are useful in detergents, foods, and pharmaceutics but their design using a single heptad remains largely unexplored. Here, four heptad surfactants were designed that are responsive to metal ions and show good emulsification properties.

Yang Li
Yilun Weng
Chun-Xia Zhao
ResearchOpen Access15 Oct 2024
Communications Materials

Volume: 5, P: 1-11
A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy

The promise of stem cell therapy for treating central nervous system disease is limited by low stem cell transplantation survival rates and poorly controlled cell fate. Here, the authors develop a biodegradable nanoscaffold for spinal cord injury that enhances transplantation and differentiation of neural stem cells and delivers drugs.

Letao Yang
Sy-Tsong Dean Chueng
Ki-Bum Lee
ResearchOpen Access08 Aug 2018
Nature Communications

Volume: 9, P: 1-14
F-box/LRR-repeat protein 12 reorchestrated microglia to inhibit scarring and achieve adult spinal cord injury repair

Xu Xu
Feng Gao
Liming Cheng
ResearchOpen Access20 Aug 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-18
Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble

The authors show that a coordinated epigenetic priming event during memory encoding and consolidation facilitates promoter–enhancer interactions that are vital for the unique transcriptional output of reactivated engram neurons.

Asaf Marco
Hiruy S. Meharena
Li-Huei Tsai
Research05 Oct 2020
Nature Neuroscience

Volume: 23, P: 1606-1617
Do translation universals exist at the syntactic-semantic level? A study using semantic role labeling and textual entailment analysis of English-Chinese translations

Letao Wang
Yue Jiang
ResearchOpen Access27 Jun 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-12
Generation of uniform-sized multicellular tumor spheroids using hydrogel microwells for advanced drug screening

Jong Min Lee
Da Yeon Park
Bong Geun Chung
ResearchOpen Access21 Nov 2018
Scientific Reports

Volume: 8, P: 1-10
Association of maternal gut microbiota and plasma metabolism with congenital heart disease in offspring: a multi-omic analysis

Tingting Wang
Lizhang Chen
Jiabi Qin
ResearchOpen Access05 Mar 2021
Scientific Reports

Volume: 11, P: 1-11

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