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Single-cell transcriptomic analysis reveals distinct cancer-associated fibroblast signatures in treatment-refractory esophageal squamous cell carcinoma

Sheng-Min Lo
Ting-Shuan Wu
Han-Ni Chuang
ResearchOpen Access04 Dec 2025
Scientific Reports

Volume: 16, P: 1-12
Transparent tissue in solid state for solvent-free and antifade 3D imaging

Current liquid-based optical clearing protocols can suffer from solvent evaporation and photobleaching. Here, the authors develop a solid high-refractive-index polymer to embed mouse and human tissues for clearing and antifade high-resolution 3D imaging.

Fu-Ting Hsiao
Hung-Jen Chien
Shiue-Cheng Tang
ResearchOpen Access09 Jun 2023
Nature Communications

Volume: 14, P: 1-12
Intravenous administration of CpG7909 lipoplex enhances anti-PD1 immunotherapy by modulating the tumor microenvironment and inducing durable tumor regression

Chia-Mu Tu
Meng-Hsuan Lin
Yu-Cheng Su
ResearchOpen Access25 Nov 2025
Scientific Reports

Volume: 15, P: 1-17