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Showing 1–20 of 20 results
Advanced filters: Author: Lia S. Campos Clear advanced filters

    • Lia Scotti Campos
    News & Views
    Nature Reviews Molecular Cell Biology
    Volume: 5, P: 341

  • The authors analyse tree responses to an extreme heat and drought event across South America to understand long-term climate resistance. While no more sensitive to this than previous lesser events, forests in drier climates showed the greatest impacts and thus vulnerability to climate extremes.

    • Amy C. Bennett
    • Thaiane Rodrigues de Sousa
    • Oliver L. Phillips
    ResearchOpen Access
    Nature Climate Change
    Volume: 13, P: 967-974

  • A vascular cell atlas integrating single-cell data of 19 organs and tissues from 62 donors identifies angiotypic and organotypic characteristics of endothelial and mural cells.

    • Sam N. Barnett
    • Ana-Maria Cujba
    • Sarah A. Teichmann
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 3468-3481

  • Genomic and epidemiologic analyses revealed that a novel reassortant viral lineage of the Oropouche virus, which has been circulating in the western Amazon region of Brazil for about a decade, is associated with the recent human outbreaks between 2022 and 2024.

    • Felipe Gomes Naveca
    • Tatiana Amaral Pires de Almeida
    • Gonzalo Bello
    Research
    Nature Medicine
    Volume: 30, P: 3509-3521

  • Multi-omics profiling of 45 human lung samples highlights 80 different cell types along the proximal to distal axis of the lung with certain cell types showing enrichment for disease-associated genes. An immune niche for IgA-expressing plasma cells within airway submucosal glands (SMG) is also identified.

    • Elo Madissoon
    • Amanda J. Oliver
    • Kerstin B. Meyer
    ResearchOpen Access
    Nature Genetics
    Volume: 55, P: 66-77

  • Cells from embryonic, fetal, paediatric and adult human intestinal tissue are analysed at different locations along the intestinal tract to construct a single-cell atlas of the developing and adult human intestinal tract, encompassing all cell lineages.

    • Rasa Elmentaite
    • Natsuhiko Kumasaka
    • Sarah A. Teichmann
    ResearchOpen Access
    Nature
    Volume: 597, P: 250-255

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Caveolae are plasma membrane invaginations playing crucial functions, like signal transduction and mechanoprotection. Here, the authors show that caveolae contribute to skin pigmentation by integrating the biochemical and mechanical response of epidermal melanocytes to extracellular cues.

    • Lia Domingues
    • Ilse Hurbain
    • Cédric Delevoye
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • Single-cell and spatial transcriptomic profiling of the human endometrium highlights pathways governing the proliferative and secretory phases of the menstrual cycle. Analyses of endometrial organoids show that WNT and NOTCH signaling modulate differentiation into the secretory and ciliated epithelial lineages, respectively.

    • Luz Garcia-Alonso
    • Louis-François Handfield
    • Roser Vento-Tormo
    ResearchOpen Access
    Nature Genetics
    Volume: 53, P: 1698-1711

  • Gao, Nowak-Imialek, Chen et al. generate porcine and human stem cells that possess expanded developmental potency for both embryonic and extra-embryonic cell lineages.

    • Xuefei Gao
    • Monika Nowak-Imialek
    • Pentao Liu
    Research
    Nature Cell Biology
    Volume: 21, P: 687-699

  • Multiple mechanisms of immune evasion exploited by cancer cells have been described. Here, the authors show that genetic inactivation or pharmacological inhibition of tumor-induced Th2-mediated de novo steroidogenesis are sufficient to restore an efficient anti-tumor immune response and restrict tumor growth.

    • Bidesh Mahata
    • Jhuma Pramanik
    • Sarah A. Teichmann
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

    • Erola Pairo-Castineira
    • Sara Clohisey
    • J. Kenneth Baillie
    Research
    Nature
    Volume: 591, P: 92-98

  • Amongst the non-small cell lung cancers, to date, lung squamous cell carcinoma remains the most challenging to treat. Here the authors report BCL11A as an important factor which together with SOX2 can drive lung squamous cell carcinoma development and highlight a potential novel therapeutic candidate for this devastating disease.

    • Kyren A. Lazarus
    • Fazal Hadi
    • Walid T. Khaled
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Cultures of expanded potential stem cells can be established from individual eight-cell blastomeres, and by direct conversion of mouse embryonic stem cells and induced pluripotent stem cells, highlighting the feasibility of establishing expanded potential stem cells for other mammalian species.

    • Jian Yang
    • David J. Ryan
    • Pentao Liu
    Research
    Nature
    Volume: 550, P: 393-397