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Showing 1–9 of 9 results
Advanced filters: Author: Liam D. Aubrey Clear advanced filters

  • Types of clonal hematopoiesis (CH) differ in frequency and fitness. These findings uncover shared genetic architecture, suggest evolutionary trade-offs between CH types, and detail elevated leukemia risk in individuals with overlapping types of CH.

    • Derek W. Brown
    • Liam D. Cato
    • Mitchell J. Machiela
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • Amyloid fibrils exhibit structural polymorphism, yet the influence of assembly environments on filament structures remains unclear. Here, the authors carried out three-dimensional reconstructions of individual fibrils using atomic force microscopy to reveal Aβ42 fibril polymorphism’s sensitivity to assembly conditions, uncovering rare species akin to those in human brains.

    • Liam D. Aubrey
    • Liisa Lutter
    • Wei-Feng Xue
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-15

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • The authors use cryo-EM to determine amyloid fibrils structures of disease relevant variants of β2-microglobulin in vitro. Each variant is polymorphic, but all polymorphs from all samples are built from a a lego-like assembly of common building blocks, suggesting a one amyloid fold’ paradigm.

    • Martin Wilkinson
    • Rodrigo U. Gallardo
    • Neil A. Ranson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • A single amyloid-forming protein or peptide can adopt many different fibrillar 3D structures, but this polymorphism is poorly understood. Here, detailed AFM imaging allows for the reconstruction of 3D models of individual fibrils which can be clustered on the basis of their individual structural properties.

    • Liam D. Aubrey
    • Ben J. F. Blakeman
    • Wei-Feng Xue
    ResearchOpen Access
    Communications Chemistry
    Volume: 3, P: 1-10

  • In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • Natalie G. Farny
    • Jiajie Zhou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-29