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Traditional fullerene-based electron transport layers in tin perovskite solar cells are costly and limit power conversion efficiency. Tianpeng Li et al. report low-cost fluorinated polymers as alternatives, achieving a certified 14.51% efficiency on 1-cm² devices.

Direct observation of the Migdal effect in neutron–nucleus collisions is reported, which resolves a long-standing gap in experimental validation.

Coordinated gene segment rearrangement across a long genomic distance is essential for antibody gene production, but how this is regulated at the chromatin level is still unclear. Here the authors show that an architectural protein, CTCF, modulates both chromatin loop extrusion and diffusion to enforce diverse Vκ gene segment utilization for a diverse Igκ repertoire.

De novosynthesis is the primary way to tune the emission colour of lanthanide-doped upconversion nanocrystals. Here, the authors introduce post-synthetic cation exchange as a strategy to access multiple colours of luminescent nanocrystals, preserving the size and morphology of the original template.

The treatment of diabetic wounds tends to be hindered by complex wound environments, and the critical role of the microenvironment in the chronic diabetic wounds has not been explored for therapeutic development. Here, the authors develop a wound microenvironment-responsive microneedle bandage to achieve self-enhanced, catabolic and dynamic therapy of chronic wounds.

Intricate regulation of gene expression is important for execution of biology processes. Here, the authors generate a comprehensive map of accessible chromatin by integrating the ATAC-seq data of 12 major maize tissues and explore their interspecific and intraspecific constraints in multiple Poaceae and maize genomes.

nip-Type tin-based perovskite solar cells have underperformed largely due to the metal oxide electron transport layers originally designed for lead-based devices. Here, authors employ metal chalcogenide as the electron transport layer, achieving enhanced efficiency up to 11.78% for stable devices.

High-throughput sequencing retrieves viral sequences from diverse environments, but these sequences can be difficult to classify. The here developed VITAP is a taxonomic assignment pipeline for DNA and RNA viruses that efficiently classifies incomplete viral sequences (as short as 1000-bp) down to genus level.

The authors report high-efficiency emission depletion through a surface migration emission depletion mechanism, which takes advantage of the effects of surface quenching and energy migration in nanocrystals. They demonstrate super-resolution microscopy with very low depletion saturation intensities.

Adipose triglyceride lipase (ATGL), an enzyme in fatty acid metabolism, was identified as a negative regulator of the noncanonical inflammasome. ATGL binds to lipopolysaccharide and catalyzes the hydrolysis of fatty acid side chains blocking inflammasome activation.

Intramolecular [5 + 2] cycloaddition reactions of oxidopyrylium ylides provide access to privileged bridged seven-membered polycyclic structures. Now, an enantioselective method enabled by a non-covalent activation strategy using chiral acid catalysis is reported, allowing multiple stereogenic centres to be constructed in one step with high efficiency, enantioselectivity and diastereoselectivity.

Water-thermal management is difficult to coordinate in solar evaporators, limiting their performance. Here, hierarchical MXene-reduced graphene oxide sponges with anisotropic thermal conductivity and axial-directional channels integrate water-thermal management for rapid and continuous evaporation.

The global race to a net-zero economy depends heavily on lithium—to power electric vehicles and to store renewable energy. Here the authors show a selective lithium extraction process from salt-lake brines, together with magnesium utilization.

Optical data storage technologies face challenges in achieving flexible, multi-level data encoding and efficient retrieval. Here, synergistic up-conversion and photo-simulated trap manipulation using co-doped Mg>sub<3 > /sub<Y>sub<2 > /sub<Ge>sub<3 > /sub < ,O>sub<12 > /sub < :Pr>sup<3 + >/sup < ,Yb>sup<3 + >/sup<storage phosphors enable rapid, high-definition data recording and secure multi-level retrieval.

It is important to understand how nanoparticles interact with biological systems and behave in vivo. This protocol describes top-down proteomics for protein corona profiling using advanced capillary zone electrophoresis–tandem mass spectrometry.

Indicine cattle make up half of all cattle populations worldwide. Using a large genomic dataset, this study finds historic migrations and extensive introgression with domestic and wild bovine species has facilitated this species physiological adaptation to extreme environments.

The protein corona on nanoparticles has potential for application in protein diagnostics. Here, the authors report on the use of small molecules to change the protein and proteoform patterns of protein corona on otherwise identical nanoparticles, which can be leveraged to significantly enhance the depth of plasma proteome profiling.

Global warming-driven deglaciation in high-mountain Asia raises the likelihood of natural dam failure and associated glacial lake outburst flood risk. This is estimated for lake development under present-day and future warming scenarios, highlighting emerging hotspots and transboundary impacts.

Colorectal cancer is discriminated by measuring cell-free RNA methylation in plasma.

Existing thermal technologies are mainly designed to harvest heat at high temperature, whilst low-grade heat is hardly utilized to date. Here, Wang et al. show an interlocked thermo-mechano feedback mechanism that transfers ambient heat to multimodal locomotions, potentially for soft robotics applications.

SERINC5 is a host-restriction factor preventing HIV progeny entry, which is counteracted by interactions with HIV Nef. Here, Li et al. show that E3 ubiquitin ligase Cullin 3 polyubiquitinates SERINC5 at Lys 130 via K48- and K33-linked ubiquitin chains and provide evidence that this modification is not only required for its membrane localization and anti-viral activity but also relevant for Nef counteractive activity.

Signal transmission without the interference from ambient light is prerequisite for optical communications. Min et al. design an asymmetric 2D-3D-2D perovskite photodetector with frequency-selective photoresponse for real-time high fidelity optical communications under strong light interference.

There are distinct hypermethylation patterns in gene promoters in hepatocellular carcinomas (HCCs). Here, the authors show that the enhancer of C/EBPβ is recurrently hypomethylated in human HCCs, recapitulating this in a transgenic murine model and linking aberrant enhancer hypomethylation to hepatocarcinogenesis.

Polyacetylene is an ideal system to probe to gain a better understanding of the nature of charge transport in conducting polymers. Now, individual atomically precise polyacetylene chains have been synthesized on a copper surface and characterized using a range of techniques, revealing a doping-induced semiconductor-to-metal transition.

Frequent heatwaves caused by global warming can lead to an increased risk of preterm birth, however, what remains unknown is the extent to which anthropogenic climate change has contributed to such burdens. Here, the authors combine health impact and economic assessment methods to comprehensively evaluate the entire preterm birth burden of heatwave exposure.

Activation of the stimulator of interferon genes (STING) can induce immunity in various cancer therapies, but delivery of STING agonists to tumours is challenging. Now a metal-based polymeric nanoparticle delivers STING agonists to tumours upon disruption of endothelial cells in tumour vasculature and targets tumour-associated macrophages, eliciting anti-tumour immune response in hard-to-treat cancer models.

Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men. Here the authors find a potential mechanistic explanation by showing that, in mice, obesity-induced STAT3 cooperates with the androgen receptor to activate the mTORC pathway through up regulation of CCRK, resulting in hepatic steatosis worsening and HCC development via metabolic and immune reprogramming.

A subtype of early-stage hepatocellular carcinoma characterized by disrupted cholesterol homeostasis and associated with a poor prognosis responds to treatment with the SOAT1 inhibitor avasimibe in a patient-derived xenograft mouse model.

Maternal RNA degradation is critical for embryogenesis and is tightly controlled by maternal RNA-binding proteins. Here the authors show that a subset of m6A-modified mRNAs regulates the dynamics of RNA-granules, thus contributes to maternal mRNA decay.

Cryo-electron microscopy structures of three adhesion G protein-coupled receptors (aGPCRs) complexes provide insight into the tethered activation mechanism of aGPCRs and show the potential for rational design of agonists.

cGAS senses viral DNA and forms cytosolic cGAS-DNA granules to mediate anti-DNA viral signaling pathway. Here the authors show that PCBP2 interacts with cGAS and antagonizes condensation of cGAS-DNA granules, thus maintaining host immune homeostasis.

Broomcorn millet is one of the oldest crops cultivated by human that has strong abiotic stress tolerance. To facilitate genome assisted breeding of this and related species, the authors report its genome assembly and conduct comparative genome structure and evolution analyses with foxtail millet.