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Showing 1–11 of 11 results

Advanced filters: Author: Liangzhen You Clear advanced filters

Chemically modified tRNA enhances the translation capacity of mRNA rich in cognate codons

The Covid-19 vaccinations showed the potential for mRNA vaccines; however, the technology still has low translation capacity. Here, the authors report on a method of improving mRNA stability and translation by overexpressing tRNAs significantly bosting protein production.

Liangzhen Dong
Jiayu Wang
Qing Xia
ResearchOpen Access22 Aug 2025
Nature Communications

Volume: 16, P: 1-18
Accurate RNA 3D structure prediction using a language model-based deep learning approach

RhoFold+ is an end-to-end language model-based deep learning method to predict RNA three-dimensional structures of single-chain RNAs from sequences.

Tao Shen
Zhihang Hu
Yu Li
ResearchOpen Access21 Nov 2024
Nature Methods

Volume: 21, P: 2287-2298
Robust enzyme discovery and engineering with deep learning using CataPro

Enzyme kinetic parameter prediction is a challenge in enzyme discovery and engineering. Here, the authors train a robust deep learning model CataPro to predict enzyme kinetic parameters and validate its practicality through wet-lab experiments.

Zechen Wang
Dongqi Xie
Liangzhen Zheng
ResearchOpen Access20 Mar 2025
Nature Communications

Volume: 16, P: 1-16
Fast, sensitive detection of protein homologs using deep dense retrieval

Protein homologs in large databases are rapidly identified with an alignment-free pipeline.

Liang Hong
Zhihang Hu
Yu Li
ResearchOpen Access09 Aug 2024
Nature Biotechnology

Volume: 43, P: 983-995
Asymptomatic infection and disappearance of clinical symptoms of COVID-19 infectors in China 2022–2023: a cross-sectional study

Kaige Zhang
Xiaoying Zhong
Hongcai Shang
ResearchOpen Access06 Aug 2024
Scientific Reports

Volume: 14, P: 1-13
Exploring the heterogeneity of cancer-related fatigue in advanced hepatocellular carcinoma patients via latent profiles and influencing factors

Juan Li
Sha Lin
Yan Tan
ResearchOpen Access08 Oct 2025
Scientific Reports

Volume: 15, P: 1-11
Amino acid insertion in Bat MHC-I enhances complex stability and augments peptide presentation

Bat MHC-I’s AA insertions boost thermal stability and peptide diversity, potentially adapting to flight-induced high temperatures and improving antiviral defenses, suggesting an evolutionary strategy to body temperature changes.

Suqiu Wang
Liangzhen Zheng
Nianzhi Zhang
ResearchOpen Access16 May 2024
Communications Biology

Volume: 7, P: 1-14
An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk, local immunosuppression and tumor progression

Liang Wu
Jiayan Yan
Jian Zhou
ResearchOpen Access19 Jun 2023
Cell Research

Volume: 33, P: 585-603
Cellobiose phosphorylase from Caldicellulosiruptor bescii catalyzes reversible phosphorolysis via different kinetic mechanisms

Shaowei Bai
Liangzhen Yang
Zuoming Zhang
ResearchOpen Access10 Mar 2022
Scientific Reports

Volume: 12, P: 1-11
Structure and Interactions of A Host Defense Antimicrobial Peptide Thanatin in Lipopolysaccharide Micelles Reveal Mechanism of Bacterial Cell Agglutination

Sheetal Sinha
Liangzhen Zheng
Surajit Bhattacharjya
ResearchOpen Access19 Dec 2017
Scientific Reports

Volume: 7, P: 1-13
Boosting the predictive performance with aqueous solubility dataset curation

Jintao Meng
Peng Chen
Wei Liu
ResearchOpen Access03 Mar 2022
Scientific Data

Volume: 9, P: 1-13