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Showing 1–3 of 3 results
Advanced filters: Author: Lianne J. Kraaier Clear advanced filters

  • Metastasis-associated oncofetal cell states emerge at the earliest stages of colorectal cancer and spatial profiling shows stereotypic patterning of fibroblast subtypes resembling normal tissue architecture, resulting in distinct regional microenvironments that dictate the timing and positioning of oncofetal plasticity.

    • Julian R. Buissant des Amorie
    • Joris H. Hageman
    • Hugo J. G. Snippert
    ResearchOpen Access
    Nature
    P: 1-11

  • WNT-activating mutations in CTNNB1 are common in hepatoblastoma, but downstream molecular phenotypes are heterogenous. Using multiomic approaches, the authors identify distinct subgroups of hepatoblastoma cells based on WNT-signaling patterns and create a biobank of patient-derived hepatoblastoma organoids representing these subtypes.

    • Thomas A. Kluiver
    • Yuyan Lu
    • Weng Chuan Peng
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17