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Showing 1–3 of 3 results
Advanced filters: Author: Lianwu Fu Clear advanced filters

  • Stop codon readthrough, the ribosomal bypass of mRNA nonsense codons, has therapeutic potential for diseases caused by nonsense mutations. Here, the authors used machine learning to define readthrough-conducive mRNA sequences and predict specific CFTR alleles likely amenable to readthrough therapy.

    • Kotchaphorn Mangkalaphiban
    • Lianwu Fu
    • Allan Jacobson
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • ARFGAP1 regulates COPI coat formation and participates in COPI-dependent trafficking. ARFGAP1 is now shown to interact with the clathrin adaptor complex AP-2 through a region distinct from its COP1-interacting domain, and to regulate transport of AP-2 cargo proteins.

    • Ming Bai
    • Helge Gad
    • Victor W. Hsu
    Research
    Nature Cell Biology
    Volume: 13, P: 559-567