Lin, Wang et al. show that a core clock transcription factor Bmal1 regulates the expression of a major drug detoxification enzyme Cyp3a11 and the daily rhythm of drug metabolism through Dbp and Hnf4α. This study suggests that Bmal1 connects circadian clock and Cyp3a11 metabolism to regulate drug detoxification as a function of daily time.
- Yanke Lin
- Shuai Wang
- Baojian Wu
