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Showing 1–4 of 4 results

Advanced filters: Author: Lida Zoupi Clear advanced filters

Flexible ensheathment of axons enables myelination of complex CNS networks

The rate of axon ensheathment varies within individual myelinating processes, resulting in chains of myelin sheaths connected by bridges consisting of thin cytoplasmic processes that provide flexibility for myelination of highly branched axons.

Cody L. Call
Sarah A. Neely
Dwight E. Bergles
ResearchOpen Access01 Apr 2026
Nature

P: 1-10
Reduced inhibition, bursting, and accelerated oscillations drive early hippocampal hyperactivity in Alzheimer’s disease in vivo

Early hippocampal hyperactivity in AD before Aβ plaque deposition could be explained in vivo by reduced inhibitory synaptic transmission with enhanced pyramidal cell bursting and accelerated neural oscillations driven by increased theta/beta rhythms.

Soraya Meftah
Sungmin Kang
Jian Gan
ResearchOpen Access28 Mar 2026
Communications Biology

Volume: 9, P: 1-18
Androgens show sex-dependent differences in myelination in immune and non-immune murine models of CNS demyelination

Androgen effects have been poorly studied in demyelinating diseases in females. Here, authors show androgen requirement for proper myelin regeneration in females and the critical need to consider male-female differences in multiple sclerosis patients.

Amina Zahaf
Abdelmoumen Kassoussi
Elisabeth Traiffort
ResearchOpen Access22 Mar 2023
Nature Communications

Volume: 14, P: 1-21
New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination

Neely et al. investigated the regeneration of different oligodendrocytes after demyelination. They found that newly generated cells exhibit much more proficient remyelination than those that survive demyelination, with implications for MS.

Sarah A. Neely
Jill M. Williamson
David A. Lyons
Research14 Feb 2022
Nature Neuroscience

Volume: 25, P: 415-420