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Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability

The conserved long noncoding RNA Chaserr is transcribed upstream of the chromatin remodeler Chd2. Here, using mouse genetics and high throughput assays, the authors show that Chaserr inhibits expression of Chd2 in cis and is required for postnatal mouse development.

Aviv Rom
Liliya Melamed
Igor Ulitsky
ResearchOpen Access08 Nov 2019
Nature Communications

Volume: 10, P: 1-15

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Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability

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