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The TRIP12 E3 ligase induces SWI/SNF component BRG1-β-catenin interaction to promote Wnt signaling

How signaling pathways recruit SWI/SNF chromatin remodeling complexes is not known. Here the authors suggest a ubiquitin directed mechanism targeting SWI/SNF for Wnt pathway dependent transcription, important for development and cancer.

Sara Kassel
Kai Yuan
Ethan Lee
ResearchOpen Access05 Jun 2025
Nature Communications

Volume: 16, P: 1-20
The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling

Wnt receptors are controlled by their ubiquitin-mediated proteolysis. The authors show that the USP46 deubiquitylase complex potentiates Wnt signaling in human cells, Xenopus, and zebrafish by inhibiting cell surface LRP6 degradation.

Victoria H. Ng
Zachary Spencer
Ethan Lee
ResearchOpen Access05 Oct 2023
Nature Communications

Volume: 14, P: 1-13
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

COVID-19 can be associated with neurological complications. Here the authors show that markers of brain injury, but not immune markers, are elevated in the blood of patients with COVID-19 both early and months after SARS-CoV-2 infection, particularly in those with brain dysfunction or neurological diagnoses.

Benedict D. Michael
Cordelia Dunai
David K. Menon
ResearchOpen Access22 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Efficient ethanol production from brown macroalgae sugars by a synthetic yeast platform

Saccharomyces cerevisiae bearing engineered alginate and mannitol catabolic pathways can ferment sugars from brown macroalgae to produce ethanol, potentially allowing the use of brown macroalgae as a viable feedstock for the production of biofuels and renewable chemicals.

Maria Enquist-Newman
Ann Marie E. Faust
Yasuo Yoshikuni
Research01 Dec 2013
Nature

Volume: 505, P: 239-243
A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

Marshall Horwitz, Charles Mullighan, Kenneth Offit and colleagues report the identification of a recurrent germline PAX5 mutation in families with pre–B cell acute lymphoblastic leukemia. They also identify sporadic cases of this leukemia with the same mutation that arose somatically.

Sohela Shah
Kasmintan A Schrader
Kenneth Offit
Research08 Sept 2013
Nature Genetics

Volume: 45, P: 1226-1231
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Benedict D. Michael
Cordelia Dunai
David K. Menon
Amendments and CorrectionsOpen Access04 Apr 2024
Nature Communications

Volume: 15, P: 1

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The TRIP12 E3 ligase induces SWI/SNF component BRG1-β-catenin interaction to promote Wnt signaling

The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Efficient ethanol production from brown macroalgae sugars by a synthetic yeast platform

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

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The TRIP12 E3 ligase induces SWI/SNF component BRG1-β-catenin interaction to promote Wnt signaling

The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Efficient ethanol production from brown macroalgae sugars by a synthetic yeast platform

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Search

Quick links