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Advanced filters: Author: Lily L. Remsing Rix Clear advanced filters

Polypharmacology-based ceritinib repurposing using integrated functional proteomics

A systems chemical biology approach to characterize beneficial off-target effects revealed a polypharmacology mechanism for the multikinase inhibitor ceritinib and a repurposing opportunity through rational design of a synergistic drug combination.

Brent M Kuenzi
Lily L Remsing Rix
Uwe Rix
Research09 Oct 2017
Nature Chemical Biology

Volume: 13, P: 1222-1231
Off-target based drug repurposing opportunities for tivantinib in acute myeloid leukemia

Brent M. Kuenzi
Lily L. Remsing Rix
Uwe Rix
ResearchOpen Access24 Jan 2019
Scientific Reports

Volume: 9, P: 1-12

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Polypharmacology-based ceritinib repurposing using integrated functional proteomics

Off-target based drug repurposing opportunities for tivantinib in acute myeloid leukemia

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