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Showing 1–4 of 4 results
Advanced filters: Author: Linda Zukley Clear advanced filters

  • Although SARS-CoV2 epitope characterization has been the focus of extensive research, these efforts have largely focused on the spike protein. Here, the authors demonstrate that CD8+ T cell responses can be directed against a dominant nucleocapsid epitope and rely on a highly focused T cell receptor repertoire.

    • Cecily Choy
    • Joseph Chen
    • Nan-Ping Weng
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • The characterisation of T cells during aging is important to predict functional outcomes in vaccination or infection. Here the authors use flow cytometry and scRNA sequencing to transcriptionally age CD8 T cells and then use a machine learning model to interpret cell age from transcriptional profiles.

    • Jian Lu
    • Raheel Ahmad
    • Nan-ping Weng
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Measuring the rate of aging holds potential for capturing heterogeneity in aging. Here, the authors use longitudinal trajectories of aging phenotypes in the Baltimore Longitudinal Study of Aging and create a longitudinal phenotypic score that is associated with accelerated decline in health and physical and cognitive function.

    • Pei-Lun Kuo
    • Jennifer A. Schrack
    • Luigi Ferrucci
    ResearchOpen Access
    Nature Aging
    Volume: 2, P: 635-643

  • As human skeletal muscle ages, gene expression programs change and reflect damage accumulation and homeostatic resilience mechanisms. Here, the authors present a detailed framework of the global transcriptome that characterizes skeletal muscle during aging in healthy individuals.

    • Robert A. Tumasian III
    • Abhinav Harish
    • Luigi Ferrucci
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16