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Showing 1–6 of 6 results
Advanced filters: Author: Lingbing Kong Clear advanced filters

  • Boron atoms in aromatic heterocycles typically behave simply as electron pair acceptors. Here, the authors report an aromatic system containing both electrophilic and nucleophilic boron atoms, and demonstrate how this imparts frustrated Lewis pair type reactivity, including binding of carbon dioxide.

    • Di Wu
    • Lingbing Kong
    • Rei Kinjo
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-6

  • The presence and linkage of unusual higher sugars in the ‘inner core’ of Gram-negative bacteria makes the core lipopolysacchride tetrasaccharide Hep2Kdo2 a tough target. Now, a 2+2 glycosylation strategy has facilitated the synthesis of this glycoconjugate. Synthesis of Hep2Kdo2 enabled an antibacterial vaccination strategy based on immunization with the glycoconjugate and the subsequent administration of an inhibitor that uncovers the corresponding epitope in pathogenic bacteria.

    • Lingbing Kong
    • Balakumar Vijayakrishnan
    • Benjamin G. Davis
    Research
    Nature Chemistry
    Volume: 8, P: 242-249

  • Emergence of tigecycline-resistance tet(X) genes is of concern. Here, the authors determine tet(X) prevalence in more than 6,000 clinical Gram-negative bacterial isolates collected between 1994 to 2019 in hospitals in China and suggest that Flavobacteriaceae could be the potential ancestral source of the tigecycline resistance genes.

    • Rong Zhang
    • Ning Dong
    • Sheng Chen
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Capsular polysaccharides are a protective layer enveloping pathogenic bacteria. Understanding their export could guide the design of therapeutics that render bacteria vulnerable to attack by the immune system or other therapeutic agents. Now, a synthetic strategy of polyglycosylation has been developed to obtain defined capsular polysaccharide fragments. Subsequent nanolitre detection enables their export to be studied at the single-molecule level.

    • Lingbing Kong
    • Andrew Almond
    • Benjamin G. Davis
    Research
    Nature Chemistry
    Volume: 8, P: 461-469

  • The assembly of transmembrane barrels formed from short synthetic peptides has not been previously demonstrated. Now, a transmembrane pore has been fabricated via the self-assembly of peptides. The 35-amino-acid α-helical peptides are based on the C-terminal D4 domain of the Escherichia coli polysaccharide transporter Wza.

    • Kozhinjampara R. Mahendran
    • Ai Niitsu
    • Hagan Bayley
    Research
    Nature Chemistry
    Volume: 9, P: 411-419

  • Capsular polysaccharides (CPS) enclose many pathogenic strains of Escherichia coli, protecting the bacteria from the host. Here, an extracellular blocker of Wza, a pore-forming protein that transports CPS to the cell surface, has been discovered by single-channel electrical recording. Treatment with the blocker exposes the bacterial cell surface and thereby facilitates killing by the human immune system.

    • Lingbing Kong
    • Leon Harrington
    • Hagan Bayley
    Research
    Nature Chemistry
    Volume: 5, P: 651-659