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Showing 1–20 of 20 results

Advanced filters: Author: Lingyin Li Clear advanced filters

Cysteine allostery and autoinhibition govern human STING oligomer functionality

Palmitoylation at C64 in stimulator of interferon genes (STING) is reported and, along with engagement of C91, is involved in dynamic cross talk with C148 to alter STING oligomer states and ultimately control STING activation.

Rebecca Chan
Xujun Cao
Lingyin Li
Research03 Jul 2025
Nature Chemical Biology

Volume: 21, P: 1611-1620
Erratum: Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

Lingyin Li
Qian Yin
Timothy J Mitchison
Amendments and Corrections18 Aug 2015
Nature Chemical Biology

Volume: 11, P: 741
Correction: Corrigendum: Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

Lingyin Li
Qian Yin
Timothy J Mitchison
Amendments and Corrections17 Feb 2015
Nature Chemical Biology

Volume: 11, P: 235
PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity

The orphan enzyme phosphotriesterase-related (PTER) is identified as a mammalian N-acetyltaurine hydrolase that has roles in regulating body weight and energy balance.

Wei Wei
Xuchao Lyu
Jonathan Z. Long
ResearchOpen Access07 Aug 2024
Nature

Volume: 633, P: 182-188
Extracellular cGAMP is a cancer-cell-produced immunotransmitter involved in radiation-induced anticancer immunity

Li and colleagues report that extracellular cGAMP produced by cancer cells acts as an immunotransmitter that, when combined with ionizing radiation, can reduce tumor volume.

Jacqueline A. Carozza
Volker Böhnert
Lingyin Li
Research24 Feb 2020
Nature Cancer

Volume: 1, P: 184-196
Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

By biochemical purification and functional validation using knockout animals, ENPP1 is now defined as a major hydrolase for 2′,3′-cGAMP, a cyclic dinucleotide generated during antiviral innate immunity. New nonhydrolyzable 2′,3′-cGAMP analogs are potent activators of this system.

Lingyin Li
Qian Yin
Timothy J Mitchison
Research26 Oct 2014
Nature Chemical Biology

Volume: 10, P: 1043-1048
Enrichment of the fetal fraction in non-invasive prenatal screening reduces maternal background interference

Bo Liang
Hong Li
Yi-Lei Zhao
ResearchOpen Access05 Dec 2018
Scientific Reports

Volume: 8, P: 1-8
Nucleotide circles of life and death

A phosphodiesterase, CdnP, from Mycobacterium tuberculosis (M. tb.) helps the pathogen evade immune detection by degrading the second messenger cyclic di-AMP that alerts the host to its presence. Genetic knockout of CdnP dampens the virulence of the pathogen, suggesting that CdnP inhibitors are potential anti–M. tb. therapeutics.

Lingyin Li
News & Views19 Jan 2017
Nature Chemical Biology

Volume: 13, P: 130-131
Discovery of VH domains that allosterically inhibit ENPP1

Phage and yeast display were used to generate variable heavy single-domain antibodies that bind and allosterically inhibit ectodomain phosphatase/phosphodiesterase-1 to increase the half-life of the immune-stimulant cyclic guanosine monophosphate adenosine monophosphate (cGAMP) in tumor microenvironments.

Paige E. Solomon
Colton J. Bracken
James A. Wells
ResearchOpen Access03 Jul 2023
Nature Chemical Biology

Volume: 20, P: 30-41
A defined glycosaminoglycan-binding substratum for human pluripotent stem cells

Defined surfaces displaying heparin-binding peptides support long-term culture of multiple human embryonic and induced pluripotent stem cell lines in defined media.

Joseph R Klim
Lingyin Li
Laura L Kiessling
Research14 Nov 2010
Nature Methods

Volume: 7, P: 989-994
Limits on the luminance of dark matter from xenon recoil data

A direct search for effective electromagnetic interactions between dark matter and xenon nuclei that produce a recoil of the latter is carried out and the first constraint on charge radius of dark matter is derived.

Xuyang Ning
Abdusalam Abdukerim
Yubo Zhou
Research17 May 2023
Nature

Volume: 618, P: 47-50
Elevated IAP in critically ill patients associated with increased AKI incidence: a cohort study from the MIMIC-IV database

ShengHui Miao
Mingkun Yang
Jing Yan
ResearchOpen Access10 Mar 2025
Scientific Reports

Volume: 15, P: 1-9
The gut microbiome is associated with brain structure and function in schizophrenia

Shijia Li
Jie Song
Kai Wu
ResearchOpen Access07 May 2021
Scientific Reports

Volume: 11, P: 1-11
Prevalence and associated risk factors of prostate cancer among a large Chinese population

Jun Chen
Liang He
Junfeng Yan
ResearchOpen Access01 Nov 2024
Scientific Reports

Volume: 14, P: 1-8
Plant pathogen resistance is mediated by recruitment of specific rhizosphere fungi

Shanshan Liu
Chengyuan Tao
George A. Kowalchuk
Research10 Apr 2023
The ISME Journal

Volume: 17, P: 931-942
Clinical subtypes identification and feature recognition of sepsis leukocyte trajectories based on machine learning

ShengHui Miao
YiJing Liu
Jing Yan
ResearchOpen Access10 Apr 2025
Scientific Reports

Volume: 15, P: 1-10
Author Correction: The gut microbiome is associated with brain structure and function in schizophrenia

Shijia Li
Jie Song
Kai Wu
Amendments and CorrectionsOpen Access30 Aug 2021
Scientific Reports

Volume: 11, P: 1-3
siRNA capsulated brain-targeted nanoparticles specifically knock down OATP2B1 in mice: a mechanism for acute morphine tolerance suppression

Zi-Zhao Yang
Li Li
Su Zeng
ResearchOpen Access15 Sept 2016
Scientific Reports

Volume: 6, P: 1-14
Increased risk of secondary bladder cancer after radiation therapy for endometrial cancer

Li Wen
Guansheng Zhong
Min Ren
ResearchOpen Access20 Jan 2022
Scientific Reports

Volume: 12, P: 1-10
Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites

Yang Liu
Jizeng Zhou
Qingjian Zou
CorrespondenceOpen Access23 Mar 2022
Cell Discovery

Volume: 8, P: 1-5